Proteolysis of fibrinogen in healthy volunteers following major and minor vivo plasminogen activation.

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Prowse CV, Dawes J, Lane DA, Ireland H, Knight I

Proteolysis of fibrinogen in healthy volunteers following major and minor vivo plasminogen activation.

Thromb Res. 1982 Jul 1;27(1):91-7. doi: 10.1016/0049-3848(82)90282-1.

PubMed ID

6750837 [ View in PubMed

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Abstract

Changes in immunoreactive fibrinopeptide A, fragment B beta 1-42 and fragment E were followed after major and minor in vivo plasminogen activation, after infusion of streptokinase and acylated streptokinase-plasminogen complex respectively, in healthy male volunteers. Major activation resulted in a dramatic rise in all three peptides, fragment E persisting in the circulation longest. Fragment B beta 1-42 was also markedly increased after minor systemic plasminogen activation despite apparently adequate levels of immediate antiplasmin.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Anistreplase	Fibrinogen alpha chain	Protein	Humans	Yes	Not Available	Details