The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.

Article Details

Citation

Barski OA, Tipparaju SM, Bhatnagar A

The aldo-keto reductase superfamily and its role in drug metabolism and detoxification.

Drug Metab Rev. 2008;40(4):553-624. doi: 10.1080/03602530802431439.

PubMed ID
18949601 [ View in PubMed
]
Abstract

The aldo-keto reductase (AKR) superfamily comprises enzymes that catalyze redox transformations involved in biosynthesis, intermediary metabolism, and detoxification. Substrates of AKRs include glucose, steroids, glycosylation end-products, lipid peroxidation products, and environmental pollutants. These proteins adopt a (beta/alpha)(8) barrel structural motif interrupted by a number of extraneous loops and helixes that vary between proteins and bring structural identity to individual families. The human AKR family differs from the rodent families. Due to their broad substrate specificity, AKRs play an important role in the phase II detoxification of a large number of pharmaceuticals, drugs, and xenobiotics.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
RutinAldo-keto reductase family 1 member C3ProteinHumans
Unknown
Not AvailableDetails