Role of protein-tyrosine phosphatases in regulation of osteoclastic activity.
Article Details
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Sheng MH, Lau KH
Role of protein-tyrosine phosphatases in regulation of osteoclastic activity.
Cell Mol Life Sci. 2009 Jun;66(11-12):1946-61. doi: 10.1007/s00018-009-8811-5.
- PubMed ID
- 19189046 [ View in PubMed]
- Abstract
Osteoclasts, the primary cell type mediating bone resorption, are multinucleated, giant cells derived from hematopoietic cells of monocyte-macrophage lineage. Osteoclast activity is, in a large part, regulated by protein-tyrosine phosphorylation. While information about functional roles of several protein-tyrosine kinases (PTK), including c-Src, in osteoclastic resorption has been accumulated, little is known about the roles of protein-tyrosine phosphatases (PTPs) in regulation of osteoclast activity. Recent evidence implicates important regulatory roles for four PTPs (SHP-1, cyt-PTP-epsilon, PTP-PEST, and PTPoc) in osteoclasts. Cyt-PTP-epsilon, PTP-PEST, and PTP-oc are positive regulators of osteoclast activity, while SHP-1 is a negative regulator. Of these PTPs in osteoclasts, only PTP-oc is a positive regulator of c-Src PTK through dephosphorylation of the inhibitory phosphotyrosine-527 residue. Although some information about mechanisms of action of these PTPs to regulate osteoclast activity is reviewed in this article, much additional work is required to provide more comprehensive details about their functions in osteoclasts.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Tiludronic acid Receptor-type tyrosine-protein phosphatase epsilon Protein Humans UnknownInhibitorDetails Tiludronic acid Tyrosine-protein phosphatase non-receptor type 12 Protein Humans UnknownInhibitorDetails Tiludronic acid Tyrosine-protein phosphatase non-receptor type 6 Protein Humans UnknownInhibitorDetails