Ifosfamide: pharmacokinetic properties for central nervous system metastasis prevention.
Article Details
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Lokiec F
Ifosfamide: pharmacokinetic properties for central nervous system metastasis prevention.
Ann Oncol. 2006 May;17 Suppl 4:iv33-6.
- PubMed ID
- 16702183 [ View in PubMed]
- Abstract
The incidence of central nervous system (CNS) recurrence in patients with lymphoma is about 5%. Nevertheless, this complication is very serious because it is almost always fatal. Its incidence is not sufficiently high to warrant the use of CNS prophylaxis in all patients. The identification of subgroups for whom CNS prophylaxis may be of benefit is therefore important and the age-adjusted international prognostic index (aa-IPI) may be useful in this respect. Ifosfamide (IFO) is a widely used antitumor agent, requiring activation to isophosphoramide mustard (IPM) for DNA alkylation. IFO anabolism occurs through the hepatic microsomal cytochrome P450 system. As with the majority of antineoplastic agents, IFO has toxic side-effects. These include neurotoxicity due to the chloroacetaldehyde (CAA) catabolite. However, the incidence of neurotoxicity is low when IFO is administered as a continuous intravenous infusion. Both inactive IFO and active IPM cross the blood-brain barrier, making IFO treatment effective in the prevention of CNS metastasis in lymphoma patients at high risk of recurrence. The benefit/risk ratio for such patients should evaluated.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ifosfamide DNA Nucleotide Humans YesOther/unknownDetails - Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Ifosfamide Cytochrome P450 2A6 Protein Humans UnknownSubstrateDetails Ifosfamide Cytochrome P450 2B6 Protein Humans UnknownSubstrateDetails Ifosfamide Cytochrome P450 2C19 Protein Humans UnknownSubstrateDetails Ifosfamide Cytochrome P450 2C8 Protein Humans UnknownSubstrateInducerDetails Ifosfamide Cytochrome P450 2C9 Protein Humans UnknownSubstrateDetails Ifosfamide Cytochrome P450 3A4 Protein Humans UnknownSubstrateInhibitorInducerDetails Ifosfamide Cytochrome P450 3A5 Protein Humans UnknownSubstrateDetails