Calcium channel functions in pain processing.

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Park J, Luo ZD

Calcium channel functions in pain processing.

Channels (Austin). 2010 Nov-Dec;4(6):510-7. doi: 10.4161/chan.4.6.12869. Epub 2010 Nov 1.

PubMed ID

21150297 [ View in PubMed

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Abstract

Voltage-gated calcium channels (VGCC) play obligatory physiological roles, including modulation of neuronal: functions, synaptic plasticity, neurotransmitter release and gene transcription. Dysregulation and maladaptive changes in VGCC expression and activities may occur in the sensory pathway under various pathological conditions that could contribute to the development of pain. In this review, we summarized the most recent findings on the regulation of VGCC expression and physiological functions in the sensory pathway, and in dysregulation and maladaptive changes of VGCC under pain-inducing conditions. The implications of: these changes in understanding the mechanisms of pain transduction and in new drug design are also discussed.

DrugBank Data that Cites this Article

Drugs

Ziconotide

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ziconotide	Voltage-dependent N-type calcium channel subunit alpha-1B	Protein	Humans	Yes	Inhibitor	Details