Adult age and ex vivo protein binding of lorazepam, oxazepam and temazepam in healthy subjects.

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Chin PK, Jensen BP, Larsen HS, Begg EJ

Adult age and ex vivo protein binding of lorazepam, oxazepam and temazepam in healthy subjects.

Br J Clin Pharmacol. 2011 Dec;72(6):985-9. doi: 10.1111/j.1365-2125.2011.04036.x.

PubMed ID

21671987 [ View in PubMed

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Abstract

AIM: To see if adult age correlates with ex vivo protein binding of lorazepam, oxazepam and temazepam in healthy subjects. METHODS: Sixty healthy drug free subjects were recruited in the age groups 18-39, 40-64 and >/=65 years. Plasma albumin concentrations were determined. Ex vivo unbound fractions (f(u)) were assessed by spiking samples and measuring the free and total concentrations. RESULTS: No correlation of age with f(u) was seen. The study was powered to demonstrate a change in f(u) of >/=7-10%. A decline in plasma albumin concentration of ~0.03 g l(-1) year(-1) was seen with increasing age (P= 0.032) and was associated with increased f(u) of lorazepam (P= 0.009) and oxazepam (P= 0.014). CONCLUSIONS: There was no association of adult age with ex vivo f(u) of lorazepam, oxazepam or temazepam in healthy subjects.

DrugBank Data that Cites this Article

Drugs

Oxazepam

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Oxazepam	Serum albumin	Protein	Humans	Unknown	Binder	Details