Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists.
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Li X, Murray WV, Jolliffe L, Pulito V
Novel arylpiperazines as selective alpha1-adrenergic receptor antagonists.
Bioorg Med Chem Lett. 2000 May 15;10(10):1093-6. doi: 10.1016/s0960-894x(00)00169-4.
- PubMed ID
- 10843225 [ View in PubMed]
- Abstract
A novel series of arylpiperazines has been synthesized and identified as antagonists of alpha1a adrenergic receptor (alpha1a-AR) implicated in benign prostatic hyperplasia. These compounds selectively bind to membrane bound alpha1a-AR with K(i)s as low as 0.66 nM. As such, these potentially represent a viable treatment for BPH without the side effects associated with known alpha1-adrenergic antagonists.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Flupentixol Alpha-1A adrenergic receptor Protein Humans UnknownAntagonistDetails