Binding of indapamide to serum proteins and erythrocytes.
Article Details
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Urien S, Riant P, Renouard A, Coulomb B, Rocher I, Tillement JP
Binding of indapamide to serum proteins and erythrocytes.
Biochem Pharmacol. 1988 Aug 1;37(15):2963-6. doi: 10.1016/0006-2952(88)90282-1.
- PubMed ID
- 3395370 [ View in PubMed]
- Abstract
The binding of indapamide to isolated serum proteins and erythrocytes was studied in order to understand its blood distribution. In serum, indapamide was mainly bound to alpha 1-acid glycoprotein with a high affinity (K = 73.4/mM), and to albumin and lipoproteins. Indapamide was bound to erythrocytes via a saturable process with a high affinity (K = 385/mM and N = 57 microM for an hematocrit value of 0.48), and erythrocytes were the main binding component in blood (more than 80% of indapamide was associated to erythrocytes in blood). The binding to serum proteins affected indapamide distribution in blood, and alpha 1-acid glycoprotein was shown to be the more effective protein in decreasing the amount of indapamide associated to erythrocytes.
DrugBank Data that Cites this Article
- Drugs
- Drug Carriers
Drug Carrier Kind Organism Pharmacological Action Actions Indapamide alpha1-acid glycoprotein (Protein Group) Protein group Humans UnknownBinderDetails Indapamide Erythrocyte Group Humans UnknownBinderDetails Indapamide Serum albumin Protein Humans UnknownBinderDetails