Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.

Article Details

Citation

Jiang J, Briede JJ, Jennen DG, Van Summeren A, Saritas-Brauers K, Schaart G, Kleinjans JC, de Kok TM

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.

Toxicol Lett. 2015 Apr 16;234(2):139-50. doi: 10.1016/j.toxlet.2015.02.012. Epub 2015 Feb 19.

PubMed ID
25704631 [ View in PubMed
]
Abstract

Acetaminophen (APAP) overdosage results in hepatotoxicity, but the underlying molecular mechanisms are still not completely understood. In the current study, we focused on mitochondrial-specific oxidative liver injury induced by APAP exposure. Owning to genetic polymorphisms in the CYP2E1 gene or varying inducibility by xenobiotics, the CYP2E1 mRNA level and protein activity vary extensively among individuals. As CYP2E1 is a known ROS generating enzyme, we chose HepG2 to minimize CYP2E1-induced ROS formation, which will help us better understand the APAP induced mitochondrial-specific hepatotoxicity in a subpopulation with low CYP2E1 activity. HepG2 cells were exposed to a low and toxic dose (0.5 and 10mM) of APAP and analyzed at four time points for genome-wide gene expression. Mitochondria were isolated and electron spin resonance spectroscopy was performed to measure the formation of mitochondrial ROS. The yield of ATP was measured to confirm the impact of the toxic dose of APAP on cellular energy production. Our results indicate that 10mM APAP significantly influences the expression of mitochondrial protein-encoding genes in association with an increase in mitochondrial ROS formation. Additionally, 10mM APAP affects the expression of genes encoding the subunits of electron transport chain (ETC) complexes, which may alter normal mitochondrial functions by disrupting the assembly, stability, and structural integrity of ETC complexes, leading to a measurable depletion of ATP, and cell death. The expression of mitochondrium-specific antioxidant enzyme, SOD2, is reduced which may limit the ROS scavenging ability and cause imbalance of the mitochondrial ROS homeostasis. Overall, transcriptome analysis reveals the molecular processes involved in the observed APAP-induced increase of mitochondrial ROS formation and the associated APAP-induced oxidative stress.

DrugBank Data that Cites this Article

Pharmaco-transcriptomics
DrugDrug GroupsGeneGene IDChangeInteractionChromosome
AcetaminophenApprovedAADAT51166
downregulated
Acetaminophen results in decreased expression of AADAT mRNA4q33
AcetaminophenApprovedABAT18
upregulated
Acetaminophen results in increased expression of ABAT mRNA16p13.2
AcetaminophenApprovedABCB1023456
upregulated
Acetaminophen results in increased expression of ABCB10 mRNA1q42.13
AcetaminophenApprovedABCE16059
downregulated
Acetaminophen results in decreased expression of ABCE1 mRNA4q31.21
AcetaminophenApprovedACAD827034
upregulated
Acetaminophen results in increased expression of ACAD8 mRNA11q25
AcetaminophenApprovedACADSB36
downregulated
Acetaminophen results in decreased expression of ACADSB mRNA10q26.13
AcetaminophenApprovedACADVL37
upregulated
Acetaminophen results in increased expression of ACADVL mRNA17p13.1
AcetaminophenApprovedACAT138
downregulated
Acetaminophen results in decreased expression of ACAT1 mRNA11q22.3
AcetaminophenApprovedACBD364746
downregulated
Acetaminophen results in decreased expression of ACBD3 mRNA1q42.12
AcetaminophenApprovedACO250
upregulated
Acetaminophen results in increased expression of ACO2 mRNA22q13.2
AcetaminophenApprovedACOT1355856
upregulated
Acetaminophen results in increased expression of ACOT13 mRNA6p22.3
AcetaminophenApprovedACOT711332
upregulated
Acetaminophen results in increased expression of ACOT7 mRNA1p36.31
AcetaminophenApprovedACP651205
downregulated
Acetaminophen results in decreased expression of ACP6 mRNA1q21.2
AcetaminophenApprovedACSF280221
upregulated
Acetaminophen results in increased expression of ACSF2 mRNA17q21.33
AcetaminophenApprovedACSL12180
upregulated
Acetaminophen results in increased expression of ACSL1 mRNA4q35.1
AcetaminophenApprovedACSL551703
downregulated
Acetaminophen results in decreased expression of ACSL5 mRNA10q25.2
AcetaminophenApprovedACSM36296
downregulated
Acetaminophen results in decreased expression of ACSM3 mRNA16p12.3
AcetaminophenApprovedACSM554988
downregulated
Acetaminophen results in decreased expression of ACSM5 mRNA16p12.3
AcetaminophenApprovedACSS184532
downregulated
Acetaminophen results in decreased expression of ACSS1 mRNA20p11.21
AcetaminophenApprovedADH5128
downregulated
Acetaminophen results in decreased expression of ADH5 mRNA4q23
AcetaminophenApprovedAFG3L210939
upregulated
Acetaminophen results in increased expression of AFG3L2 mRNA18p11.21
AcetaminophenApprovedAGK55750
upregulated
Acetaminophen results in increased expression of AGK mRNA7q34
AcetaminophenApprovedAGMAT79814
downregulated
Acetaminophen results in decreased expression of AGMAT mRNA1p36.21
AcetaminophenApprovedAGPAT555326
downregulated
Acetaminophen results in decreased expression of AGPAT5 mRNA8p23.1
AcetaminophenApprovedAGPS8540
downregulated
Acetaminophen results in decreased expression of AGPS mRNA2q31.2
AcetaminophenApprovedAGXT189
downregulated
Acetaminophen results in decreased expression of AGXT mRNA2q37.3
AcetaminophenApprovedAIFM19131
downregulated
Acetaminophen results in decreased expression of AIFM1 mRNAXq26.1
AcetaminophenApprovedAIFM284883
downregulated
Acetaminophen results in decreased expression of AIFM2 mRNA10q22.1
AcetaminophenApprovedAK2204
downregulated
Acetaminophen results in decreased expression of AK2 mRNA1p35.1
AcetaminophenApprovedAK4205
downregulated
Acetaminophen results in decreased expression of AK4 mRNA1p31.3
AcetaminophenApprovedAKAP18165
downregulated
Acetaminophen results in decreased expression of AKAP1 mRNA17q22
AcetaminophenApprovedAKR7A28574
upregulated
Acetaminophen results in increased expression of AKR7A2 mRNA1p36.13
AcetaminophenApprovedALDH18A15832
downregulated
Acetaminophen results in decreased expression of ALDH18A1 mRNA10q24.1
AcetaminophenApprovedALDH1B1219
downregulated
Acetaminophen results in decreased expression of ALDH1B1 mRNA9p13.1
AcetaminophenApprovedALDH2217
downregulated
Acetaminophen results in decreased expression of ALDH2 mRNA12q24.12
AcetaminophenApprovedALDH3A2224
downregulated
Acetaminophen results in decreased expression of ALDH3A2 mRNA17p11.2
AcetaminophenApprovedALDH6A14329
downregulated
Acetaminophen results in decreased expression of ALDH6A1 mRNA14q24.3
AcetaminophenApprovedAMT275
downregulated
Acetaminophen results in decreased expression of AMT mRNA3p21.31
AcetaminophenApprovedAPEX227301
upregulated
Acetaminophen results in increased expression of APEX2 mRNAXp11.21
AcetaminophenApprovedARAF369
upregulated
Acetaminophen results in increased expression of ARAF mRNAXp11.3
AcetaminophenApprovedARL2BP23568
upregulated
Acetaminophen results in increased expression of ARL2BP mRNA16q13
AcetaminophenApprovedARSB411
downregulated
Acetaminophen results in decreased expression of ARSB mRNA5q14.1
AcetaminophenApprovedATP5B506
downregulated
Acetaminophen results in decreased expression of ATP5B mRNA12q13.3
AcetaminophenApprovedATP5D513
downregulated
Acetaminophen results in decreased expression of ATP5D mRNA19p13.3
AcetaminophenApprovedATP5E514
downregulated
Acetaminophen results in decreased expression of ATP5E mRNA20q13.32
AcetaminophenApprovedATP5I521
downregulated
Acetaminophen results in decreased expression of ATP5I mRNA4p16.3
AcetaminophenApprovedATP5L10632
upregulated
Acetaminophen results in increased expression of ATP5L mRNA11q23.3
AcetaminophenApprovedATP5S27109
upregulated
Acetaminophen results in increased expression of ATP5S mRNA14q21.3
AcetaminophenApprovedATP6V1E1529
upregulated
Acetaminophen results in increased expression of ATP6V1E1 mRNA22q11.21
AcetaminophenApprovedATP7B540
downregulated
Acetaminophen results in decreased expression of ATP7B mRNA13q14.3
AcetaminophenApprovedATPAF291647
upregulated
Acetaminophen results in increased expression of ATPAF2 mRNA17p11.2
AcetaminophenApprovedATPIF193974
downregulated
Acetaminophen results in decreased expression of ATPIF1 mRNA1p35.3
AcetaminophenApprovedAUH549
downregulated
Acetaminophen results in decreased expression of AUH mRNA9q22.31
AcetaminophenApprovedAZIN2113451
upregulated
Acetaminophen results in increased expression of AZIN2 mRNA1p35.1
AcetaminophenApprovedBAD572
upregulated
Acetaminophen results in increased expression of BAD mRNA11q13.1
AcetaminophenApprovedBCL2L1110018
upregulated
Acetaminophen results in increased expression of BCL2L11 mRNA2q13
AcetaminophenApprovedBCL2L1323786
upregulated
Acetaminophen results in increased expression of BCL2L13 mRNA22q11.21
AcetaminophenApprovedBDH1622
downregulated
Acetaminophen results in decreased expression of BDH1 mRNA3q29
AcetaminophenApprovedBID637
downregulated
Acetaminophen results in decreased expression of BID mRNA22q11.21
AcetaminophenApprovedBIK638
upregulated
Acetaminophen results in increased expression of BIK mRNA22q13.2
AcetaminophenApprovedBNIP3664
downregulated
Acetaminophen results in decreased expression of BNIP3 mRNA10q26.3
AcetaminophenApprovedBNIP3L665
downregulated
Acetaminophen results in decreased expression of BNIP3L mRNA8p21.2
AcetaminophenApprovedBPHL670
upregulated
Acetaminophen results in increased expression of BPHL mRNA6p25.2
AcetaminophenApprovedBRD810902
upregulated
Acetaminophen results in increased expression of BRD8 mRNA5q31.2
AcetaminophenApprovedC1QBP708
downregulated
Acetaminophen results in decreased expression of C1QBP mRNA17p13.2
AcetaminophenApprovedCA5A763
downregulated
Acetaminophen results in decreased expression of CA5A mRNA16q24.2
AcetaminophenApprovedCAPRIN265981
upregulated
Acetaminophen results in increased expression of CAPRIN2 mRNA12p11.21
AcetaminophenApprovedCARS279587
downregulated
Acetaminophen results in decreased expression of CARS2 mRNA13q34
AcetaminophenApprovedCCDC90B60492
upregulated
Acetaminophen results in increased expression of CCDC90B mRNA11q14.1
AcetaminophenApprovedCEP8984902
upregulated
Acetaminophen results in increased expression of CEP89 mRNA19q13.11
AcetaminophenApprovedCHAF1B8208
upregulated
Acetaminophen results in increased expression of CHAF1B mRNA21q22.12-q22.13
AcetaminophenApprovedCHDH55349
downregulated
Acetaminophen results in decreased expression of CHDH mRNA3p21.1
AcetaminophenApprovedCISD155847
downregulated
Acetaminophen results in decreased expression of CISD1 mRNA10q21.1
AcetaminophenApprovedCKMT21160
downregulated
Acetaminophen results in decreased expression of CKMT2 mRNA5q14.1
AcetaminophenApprovedCLN31201
downregulated
Acetaminophen results in decreased expression of CLN3 mRNA16p12.1
AcetaminophenApprovedCLPP8192
downregulated
Acetaminophen results in decreased expression of CLPP mRNA19p13.3
AcetaminophenApprovedCLPX10845
downregulated
Acetaminophen results in decreased expression of CLPX mRNA15q22.31
AcetaminophenApprovedCLU1191
upregulated
Acetaminophen results in increased expression of CLU mRNA8p21.1
AcetaminophenApprovedCLYBL171425
upregulated
Acetaminophen results in increased expression of CLYBL mRNA13q32.3
AcetaminophenApprovedCOA328958
downregulated
Acetaminophen results in decreased expression of COA3 mRNA17q21.2
AcetaminophenApprovedCOA6388753
downregulated
Acetaminophen results in decreased expression of COA6 mRNA1q42.2
AcetaminophenApprovedCOG884342
downregulated
Acetaminophen results in decreased expression of COG8 mRNA16q22.1
AcetaminophenApprovedCOL4A3BP10087
downregulated
Acetaminophen results in decreased expression of COL4A3BP mRNA5q13.3
AcetaminophenApprovedCOQ10A93058
upregulated
Acetaminophen results in increased expression of COQ10A mRNA12q13.3
AcetaminophenApprovedCOQ227235
upregulated
Acetaminophen results in increased expression of COQ2 mRNA4q21.23
AcetaminophenApprovedCOQ351805
downregulated
Acetaminophen results in decreased expression of COQ3 mRNA6q16.2
AcetaminophenApprovedCOQ451117
downregulated
Acetaminophen results in decreased expression of COQ4 mRNA9q34.11
AcetaminophenApprovedCOQ584274
upregulated
Acetaminophen results in increased expression of COQ5 mRNA12q24.31
AcetaminophenApprovedCOQ8A56997
downregulated
Acetaminophen results in decreased expression of COQ8A mRNA1q42.13
AcetaminophenApprovedCOX101352
downregulated
Acetaminophen results in decreased expression of COX10 mRNA17p12
AcetaminophenApprovedCOX111353
downregulated
Acetaminophen results in decreased expression of COX11 mRNA17q22
AcetaminophenApprovedCOX151355
upregulated
Acetaminophen results in increased expression of COX15 mRNA10q24.2
AcetaminophenApprovedCOX5A9377
downregulated
Acetaminophen results in decreased expression of COX5A mRNA15q24.2
AcetaminophenApprovedCOX6B11340
upregulated
Acetaminophen results in increased expression of COX6B1 mRNA19q13.12
AcetaminophenApprovedCOX6C1345
upregulated
Acetaminophen results in increased expression of COX6C mRNA8q22.2
AcetaminophenApprovedCOX7A21347
upregulated
Acetaminophen results in increased expression of COX7A2 mRNA6q14.1
AcetaminophenApprovedCOX7A2L9167
upregulated
Acetaminophen results in increased expression of COX7A2L mRNA2p21
AcetaminophenApprovedCOX7B1349
upregulated
Acetaminophen results in increased expression of COX7B mRNAXq21.1
AcetaminophenApprovedCOX8A1351
upregulated
Acetaminophen results in increased expression of COX8A mRNA11q13.1
AcetaminophenApprovedCPOX1371
upregulated
Acetaminophen results in increased expression of CPOX mRNA3q11.2
AcetaminophenApprovedCPS11373
downregulated
Acetaminophen results in decreased expression of CPS1 mRNA2q34
AcetaminophenApprovedCRLS154675
downregulated
Acetaminophen results in decreased expression of CRLS1 mRNA20p12.3
AcetaminophenApprovedCRY11407
upregulated
Acetaminophen results in increased expression of CRY1 mRNA12q23.3
AcetaminophenApprovedCSDE17812
downregulated
Acetaminophen results in decreased expression of CSDE1 mRNA1p13.2
AcetaminophenApprovedCTSA5476
upregulated
Acetaminophen results in increased expression of CTSA mRNA20q13.12
AcetaminophenApprovedCTSB1508
upregulated
Acetaminophen results in increased expression of CTSB mRNA8p23.1
AcetaminophenApprovedCYB5A1528
downregulated
Acetaminophen results in decreased expression of CYB5A mRNA18q22.3
AcetaminophenApprovedCYB5B80777
downregulated
Acetaminophen results in decreased expression of CYB5B mRNA16q22.1
AcetaminophenApprovedCYBA1535
upregulated
Acetaminophen results in increased expression of CYBA mRNA16q24.2
AcetaminophenApprovedCYC11537
downregulated
Acetaminophen results in decreased expression of CYC1 mRNA8q24.3
AcetaminophenApprovedCYCS54205
upregulated
Acetaminophen results in increased expression of CYCS mRNA7p15.3
AcetaminophenApprovedCYP1A11543
upregulated
Acetaminophen results in increased expression of CYP1A1 mRNA15q24.1
AcetaminophenApprovedCYP27A11593
downregulated
Acetaminophen results in decreased expression of CYP27A1 mRNA2q35
AcetaminophenApprovedCYP27B11594
downregulated
Acetaminophen results in decreased expression of CYP27B1 mRNA12q14.1
AcetaminophenApprovedDAP37818
downregulated
Acetaminophen results in decreased expression of DAP3 mRNA1q22
AcetaminophenApprovedDECR11666
downregulated
Acetaminophen results in decreased expression of DECR1 mRNA8q21.3
AcetaminophenApprovedDGUOK1716
downregulated
Acetaminophen results in decreased expression of DGUOK mRNA2p13.1
AcetaminophenApprovedDHODH1723
downregulated
Acetaminophen results in decreased expression of DHODH mRNA16q22.2
AcetaminophenApprovedDHRS1115817
downregulated
Acetaminophen results in decreased expression of DHRS1 mRNA14q12
AcetaminophenApprovedDHRS210202
upregulated
Acetaminophen results in increased expression of DHRS2 mRNA14q11.2
AcetaminophenApprovedDHTKD155526
upregulated
Acetaminophen results in increased expression of DHTKD1 mRNA10p14
AcetaminophenApprovedDHX3022907
downregulated
Acetaminophen results in decreased expression of DHX30 mRNA3p21.31
AcetaminophenApprovedDIABLO56616
upregulated
Acetaminophen results in increased expression of DIABLO mRNA12q24.31
AcetaminophenApprovedDLAT1737
downregulated
Acetaminophen results in decreased expression of DLAT mRNA11q23.1
AcetaminophenApprovedDNA21763
upregulated
Acetaminophen results in increased expression of DNA2 mRNA10q21.3
AcetaminophenApprovedDNAJA39093
downregulated
Acetaminophen results in decreased expression of DNAJA3 mRNA16p13.3
AcetaminophenApprovedDNAJC1155735
downregulated
Acetaminophen results in decreased expression of DNAJC11 mRNA1p36.31
AcetaminophenApprovedDNAJC19131118
downregulated
Acetaminophen results in decreased expression of DNAJC19 mRNA3q26.33
AcetaminophenApprovedDNM1L10059
upregulated
Acetaminophen results in increased expression of DNM1L mRNA12p11.21
AcetaminophenApprovedDPYSL21808
upregulated
Acetaminophen results in increased expression of DPYSL2 mRNA8p21.2
AcetaminophenApprovedDTD192675
downregulated
Acetaminophen results in decreased expression of DTD1 mRNA20p11.23
AcetaminophenApprovedE2F11869
upregulated
Acetaminophen results in increased expression of E2F1 mRNA20q11.22
AcetaminophenApprovedEARS2124454
downregulated
Acetaminophen results in decreased expression of EARS2 mRNA16p12.2
AcetaminophenApprovedECH11891
downregulated
Acetaminophen results in decreased expression of ECH1 mRNA19q13.2
AcetaminophenApprovedECHDC255268
downregulated
Acetaminophen results in decreased expression of ECHDC2 mRNA1p32.3
AcetaminophenApprovedECI210455
downregulated
Acetaminophen results in decreased expression of ECI2 mRNA6p25.2
AcetaminophenApprovedEHHADH1962
downregulated
Acetaminophen results in decreased expression of EHHADH mRNA3q27.2
AcetaminophenApprovedELOVL679071
downregulated
Acetaminophen results in decreased expression of ELOVL6 mRNA4q25
AcetaminophenApprovedEMC810328
downregulated
Acetaminophen results in decreased expression of EMC8 mRNA16q24.1
AcetaminophenApprovedENDOG2021
downregulated
Acetaminophen results in decreased expression of ENDOG mRNA9q34.11
AcetaminophenApprovedENOSF155556
downregulated
Acetaminophen results in decreased expression of ENOSF1 mRNA18p11.32
AcetaminophenApprovedETFB2109
downregulated
Acetaminophen results in decreased expression of ETFB mRNA19q13.41
AcetaminophenApprovedETFDH2110
upregulated
Acetaminophen results in increased expression of ETFDH mRNA4q32.1
AcetaminophenApprovedFAHD181889
downregulated
Acetaminophen results in decreased expression of FAHD1 mRNA16p13.3
AcetaminophenApprovedFAM110B90362
downregulated
Acetaminophen results in decreased expression of FAM110B mRNA8q12.1
AcetaminophenApprovedFAM136A84908
downregulated
Acetaminophen results in decreased expression of FAM136A mRNA2p13.3
AcetaminophenApprovedFDXR2232
upregulated
Acetaminophen results in increased expression of FDXR mRNA17q25.1
AcetaminophenApprovedFECH2235
upregulated
Acetaminophen results in increased expression of FECH mRNA18q21.31
AcetaminophenApprovedFEN12237
upregulated
Acetaminophen results in increased expression of FEN1 mRNA11q12.2
AcetaminophenApprovedFIS151024
downregulated
Acetaminophen results in decreased expression of FIS1 mRNA7q22.1
AcetaminophenApprovedFPGS2356
downregulated
Acetaminophen results in decreased expression of FPGS mRNA9q34.11
AcetaminophenApprovedFRMD6122786
upregulated
Acetaminophen results in increased expression of FRMD6 mRNA14q22.1
AcetaminophenApprovedFXN2395
downregulated
Acetaminophen results in decreased expression of FXN mRNA9q21.11
AcetaminophenApprovedGATB5188
downregulated
Acetaminophen results in decreased expression of GATB mRNA4q31.3
AcetaminophenApprovedGATM2628
downregulated
Acetaminophen results in decreased expression of GATM mRNA15q21.1
AcetaminophenApprovedGCAT23464
upregulated
Acetaminophen results in increased expression of GCAT mRNA22q13.1
AcetaminophenApprovedGCDH2639
upregulated
Acetaminophen results in increased expression of GCDH mRNA19p13.13
AcetaminophenApprovedGFER2671
downregulated
Acetaminophen results in decreased expression of GFER mRNA16p13.3
AcetaminophenApprovedGLDC2731
downregulated
Acetaminophen results in decreased expression of GLDC mRNA9p24.1
AcetaminophenApprovedGLOD451031
downregulated
Acetaminophen results in decreased expression of GLOD4 mRNA17p13.3
AcetaminophenApprovedGLS2744
upregulated
Acetaminophen results in increased expression of GLS mRNA2q32.2
AcetaminophenApprovedGLS227165
upregulated
Acetaminophen results in increased expression of GLS2 mRNA12q13.3
AcetaminophenApprovedGLT8D155830
downregulated
Acetaminophen results in decreased expression of GLT8D1 mRNA3p21.1
AcetaminophenApprovedGLUD22747
downregulated
Acetaminophen results in decreased expression of GLUD2 mRNAXq24
AcetaminophenApprovedGLYCTK132158
downregulated
Acetaminophen results in decreased expression of GLYCTK mRNA3p21.2
AcetaminophenApprovedGM2A2760
upregulated
Acetaminophen results in increased expression of GM2A mRNA5q33.1
AcetaminophenApprovedGPAM57678
downregulated
Acetaminophen results in decreased expression of GPAM mRNA10q25.2
AcetaminophenApprovedGPRC5C55890
downregulated
Acetaminophen results in decreased expression of GPRC5C mRNA17q25.1
AcetaminophenApprovedGPX42879
upregulated
Acetaminophen results in increased expression of GPX4 mRNA19p13.3
AcetaminophenApprovedGRN2896
upregulated
Acetaminophen results in increased expression of GRN mRNA17q21.31
AcetaminophenApprovedGRPEL180273
downregulated
Acetaminophen results in decreased expression of GRPEL1 mRNA4p16.1
AcetaminophenApprovedGRPEL2134266
downregulated
Acetaminophen results in decreased expression of GRPEL2 mRNA5q32
AcetaminophenApprovedGSTK1373156
upregulated
Acetaminophen results in increased expression of GSTK1 mRNA7q34
AcetaminophenApprovedGSTZ12954
upregulated
Acetaminophen results in increased expression of GSTZ1 mRNA14q24.3
AcetaminophenApprovedGTF3C22976
downregulated
Acetaminophen results in decreased expression of GTF3C2 mRNA2p23.3
AcetaminophenApprovedHAGH3029
upregulated
Acetaminophen results in increased expression of HAGH mRNA16p13.3
AcetaminophenApprovedHARS223438
downregulated
Acetaminophen results in decreased expression of HARS2 mRNA5q31.3
AcetaminophenApprovedHEBP150865
upregulated
Acetaminophen results in increased expression of HEBP1 mRNA12p13.1
AcetaminophenApprovedHEBP223593
downregulated
Acetaminophen results in decreased expression of HEBP2 mRNA6q24.1
AcetaminophenApprovedHIBADH11112
upregulated
Acetaminophen results in increased expression of HIBADH mRNA7p15.2
AcetaminophenApprovedHINT284681
upregulated
Acetaminophen results in increased expression of HINT2 mRNA9p13.3
AcetaminophenApprovedHK13098
upregulated
Acetaminophen results in increased expression of HK1 mRNA10q22.1
AcetaminophenApprovedHKDC180201
downregulated
Acetaminophen results in decreased expression of HKDC1 mRNA10q22.1
AcetaminophenApprovedHMBS3145
upregulated
Acetaminophen results in increased expression of HMBS mRNA11q23.3
AcetaminophenApprovedHMGCL3155
upregulated
Acetaminophen results in increased expression of HMGCL mRNA1p36.11
AcetaminophenApprovedHSD17B103028
downregulated
Acetaminophen results in decreased expression of HSD17B10 mRNAXp11.22
AcetaminophenApprovedHSD17B43295
downregulated
Acetaminophen results in decreased expression of HSD17B4 mRNA5q23.1
AcetaminophenApprovedHSPA1A3303
upregulated
Acetaminophen results in increased expression of HSPA1A mRNA6p21.33
AcetaminophenApprovedHSPA1B3304
upregulated
Acetaminophen results in increased expression of HSPA1B mRNA6p21.33
AcetaminophenApprovedHSPA93313
downregulated
Acetaminophen results in decreased expression of HSPA9 mRNA5q31.2
AcetaminophenApprovedHSPE13336
downregulated
Acetaminophen results in decreased expression of HSPE1 mRNA2q33.1
AcetaminophenApprovedHTRA227429
upregulated
Acetaminophen results in increased expression of HTRA2 mRNA2p13.1
AcetaminophenApprovedIARS255699
downregulated
Acetaminophen results in decreased expression of IARS2 mRNA1q41
AcetaminophenApprovedIDH23418
upregulated
Acetaminophen results in increased expression of IDH2 mRNA15q26.1
AcetaminophenApprovedIDH3A3419
upregulated
Acetaminophen results in increased expression of IDH3A mRNA15q25.1
AcetaminophenApprovedIDH3B3420
downregulated
Acetaminophen results in decreased expression of IDH3B mRNA20p13
AcetaminophenApprovedIFI62537
upregulated
Acetaminophen results in increased expression of IFI6 mRNA1p35.3
AcetaminophenApprovedILF33609
downregulated
Acetaminophen results in decreased expression of ILF3 mRNA19p13.2
AcetaminophenApprovedIMMP1L196294
downregulated
Acetaminophen results in decreased expression of IMMP1L mRNA11p13
AcetaminophenApprovedIMMT10989
upregulated
Acetaminophen results in increased expression of IMMT mRNA2p11.2
AcetaminophenApprovedISCA2122961
upregulated
Acetaminophen results in increased expression of ISCA2 mRNA14q24.3
AcetaminophenApprovedISCU23479
upregulated
Acetaminophen results in increased expression of ISCU mRNA12q23.3
AcetaminophenApprovedISOC279763
downregulated
Acetaminophen results in decreased expression of ISOC2 mRNA19q13.42
AcetaminophenApprovedIVD3712
downregulated
Acetaminophen results in decreased expression of IVD mRNA15q15.1
AcetaminophenApprovedKARS3735
downregulated
Acetaminophen results in decreased expression of KARS mRNA16q23.1
AcetaminophenApprovedKIAA03919692
downregulated
Acetaminophen results in decreased expression of KIAA0391 mRNA14q13.2
AcetaminophenApprovedKIF1BP26128
upregulated
Acetaminophen results in increased expression of KIF1BP mRNA10q22.1
AcetaminophenApprovedKYNU8942
downregulated
Acetaminophen results in decreased expression of KYNU mRNA2q22.2
AcetaminophenApprovedL2HGDH79944
upregulated
Acetaminophen results in increased expression of L2HGDH mRNA14q21.3
AcetaminophenApprovedLACTB114294
upregulated
Acetaminophen results in increased expression of LACTB mRNA15q22.2
AcetaminophenApprovedLAP351056
downregulated
Acetaminophen results in decreased expression of LAP3 mRNA4p15.32
AcetaminophenApprovedLARS223395
downregulated
Acetaminophen results in decreased expression of LARS2 mRNA3p21.31
AcetaminophenApprovedLDHD197257
upregulated
Acetaminophen results in increased expression of LDHD mRNA16q23.1
AcetaminophenApprovedLETM13954
downregulated
Acetaminophen results in decreased expression of LETM1 mRNA4p16.3
AcetaminophenApprovedLIMK23985
upregulated
Acetaminophen results in increased expression of LIMK2 mRNA22q12.2
AcetaminophenApprovedLONP19361
downregulated
Acetaminophen results in decreased expression of LONP1 mRNA19p13.2
AcetaminophenApprovedLRRC5955379
downregulated
Acetaminophen results in decreased expression of LRRC59 mRNA17q21.33
AcetaminophenApprovedLYPLA110434
downregulated
Acetaminophen results in decreased expression of LYPLA1 mRNA8q11.23
AcetaminophenApprovedLYRM457128
downregulated
Acetaminophen results in decreased expression of LYRM4 mRNA6p25.1
AcetaminophenApprovedMAIP179568
downregulated
Acetaminophen results in decreased expression of MAIP1 mRNA2q33.1
AcetaminophenApprovedMAOA4128
downregulated
Acetaminophen results in decreased expression of MAOA mRNAXp11.3
AcetaminophenApprovedMAOB4129
downregulated
Acetaminophen results in decreased expression of MAOB mRNAXp11.3
AcetaminophenApprovedMARC164757
downregulated
Acetaminophen results in decreased expression of MARC1 mRNA1q41
AcetaminophenApprovedMARC254996
upregulated
Acetaminophen results in increased expression of MARC2 mRNA1q41
AcetaminophenApprovedMCCC156922
downregulated
Acetaminophen results in decreased expression of MCCC1 mRNA3q27.1
AcetaminophenApprovedMCCC264087
downregulated
Acetaminophen results in decreased expression of MCCC2 mRNA5q13.2
AcetaminophenApprovedMCEE84693
downregulated
Acetaminophen results in decreased expression of MCEE mRNA2p13.3
AcetaminophenApprovedME24200
upregulated
Acetaminophen results in increased expression of ME2 mRNA18q21.2
AcetaminophenApprovedMETAP1D254042
downregulated
Acetaminophen results in decreased expression of METAP1D mRNA2q31.1
AcetaminophenApprovedMETTL12751071
upregulated
Acetaminophen results in increased expression of METTL12 mRNA11q12.3
AcetaminophenApprovedMETTL1764745
downregulated
Acetaminophen results in decreased expression of METTL17 mRNA14q11.2
AcetaminophenApprovedMIEF154471
downregulated
Acetaminophen results in decreased expression of MIEF1 mRNA22q13.1
AcetaminophenApprovedMIPEP4285
upregulated
Acetaminophen results in increased expression of MIPEP mRNA13q12.12
AcetaminophenApprovedMMADHC27249
downregulated
Acetaminophen results in decreased expression of MMADHC mRNA2q23.2
AcetaminophenApprovedMPC225874
downregulated
Acetaminophen results in decreased expression of MPC2 mRNA1q24.2
AcetaminophenApprovedMPV174358
upregulated
Acetaminophen results in increased expression of MPV17 mRNA2p23.3
AcetaminophenApprovedMRPL165008
downregulated
Acetaminophen results in decreased expression of MRPL1 mRNA4q21.1
AcetaminophenApprovedMRPL10124995
upregulated
Acetaminophen results in increased expression of MRPL10 mRNA17q21.32
AcetaminophenApprovedMRPL1165003
downregulated
Acetaminophen results in decreased expression of MRPL11 mRNA11q13.2
AcetaminophenApprovedMRPL126182
downregulated
Acetaminophen results in decreased expression of MRPL12 mRNA17q25.3
AcetaminophenApprovedMRPL1529088
downregulated
Acetaminophen results in decreased expression of MRPL15 mRNA8q11.23
AcetaminophenApprovedMRPL1654948
downregulated
Acetaminophen results in decreased expression of MRPL16 mRNA11q12.1
AcetaminophenApprovedMRPL199801
downregulated
Acetaminophen results in decreased expression of MRPL19 mRNA2p12
AcetaminophenApprovedMRPL2229093
downregulated
Acetaminophen results in decreased expression of MRPL22 mRNA5q33.2
AcetaminophenApprovedMRPL236150
downregulated
Acetaminophen results in decreased expression of MRPL23 mRNA11p15.5
AcetaminophenApprovedMRPL2810573
downregulated
Acetaminophen results in decreased expression of MRPL28 mRNA16p13.3
AcetaminophenApprovedMRPL311222
downregulated
Acetaminophen results in decreased expression of MRPL3 mRNA3q22.1
AcetaminophenApprovedMRPL3264983
downregulated
Acetaminophen results in decreased expression of MRPL32 mRNA7p14.1
AcetaminophenApprovedMRPL3464981
downregulated
Acetaminophen results in decreased expression of MRPL34 mRNA19p13.1
AcetaminophenApprovedMRPL3551318
downregulated
Acetaminophen results in decreased expression of MRPL35 mRNA2p11.2
AcetaminophenApprovedMRPL3954148
downregulated
Acetaminophen results in decreased expression of MRPL39 mRNA21q21.3
AcetaminophenApprovedMRPL451073
downregulated
Acetaminophen results in decreased expression of MRPL4 mRNA19p13.2
AcetaminophenApprovedMRPL4064976
upregulated
Acetaminophen results in increased expression of MRPL40 mRNA22q11.21
AcetaminophenApprovedMRPL4164975
upregulated
Acetaminophen results in increased expression of MRPL41 mRNA9q34.3
AcetaminophenApprovedMRPL4384545
downregulated
Acetaminophen results in decreased expression of MRPL43 mRNA10q24.31
AcetaminophenApprovedMRPL4465080
downregulated
Acetaminophen results in decreased expression of MRPL44 mRNA2q36.1
AcetaminophenApprovedMRPL4626589
downregulated
Acetaminophen results in decreased expression of MRPL46 mRNA15q25.3
AcetaminophenApprovedMRPL4851642
downregulated
Acetaminophen results in decreased expression of MRPL48 mRNA11q13.4
AcetaminophenApprovedMRPL5054534
downregulated
Acetaminophen results in decreased expression of MRPL50 mRNA9q31.1
AcetaminophenApprovedMRPL54116541
downregulated
Acetaminophen results in decreased expression of MRPL54 mRNA19p13.3
AcetaminophenApprovedMRPL965005
downregulated
Acetaminophen results in decreased expression of MRPL9 mRNA1q21.3
AcetaminophenApprovedMRPS1055173
upregulated
Acetaminophen results in increased expression of MRPS10 mRNA6p21.1
AcetaminophenApprovedMRPS1164963
upregulated
Acetaminophen results in increased expression of MRPS11 mRNA15q25.3
AcetaminophenApprovedMRPS126183
downregulated
Acetaminophen results in decreased expression of MRPS12 mRNA19q13.2
AcetaminophenApprovedMRPS1564960
downregulated
Acetaminophen results in decreased expression of MRPS15 mRNA1p34.3
AcetaminophenApprovedMRPS18B28973
downregulated
Acetaminophen results in decreased expression of MRPS18B mRNA6p21.33
AcetaminophenApprovedMRPS251116
downregulated
Acetaminophen results in decreased expression of MRPS2 mRNA9q34.3
AcetaminophenApprovedMRPS2154460
upregulated
Acetaminophen results in increased expression of MRPS21 mRNA1q21.2
AcetaminophenApprovedMRPS2351649
downregulated
Acetaminophen results in decreased expression of MRPS23 mRNA17q22
AcetaminophenApprovedMRPS2664949
downregulated
Acetaminophen results in decreased expression of MRPS26 mRNA20p13
AcetaminophenApprovedMRPS2723107
downregulated
Acetaminophen results in decreased expression of MRPS27 mRNA5q13.2
AcetaminophenApprovedMRPS2828957
downregulated
Acetaminophen results in decreased expression of MRPS28 mRNA8q21.13
AcetaminophenApprovedMRPS3010884
downregulated
Acetaminophen results in decreased expression of MRPS30 mRNA5p12
AcetaminophenApprovedMRPS3351650
upregulated
Acetaminophen results in increased expression of MRPS33 mRNA7q34
AcetaminophenApprovedMRPS3465993
downregulated
Acetaminophen results in decreased expression of MRPS34 mRNA16p13.3
AcetaminophenApprovedMRPS3560488
downregulated
Acetaminophen results in decreased expression of MRPS35 mRNA12p11.22
AcetaminophenApprovedMRPS3692259
downregulated
Acetaminophen results in decreased expression of MRPS36 mRNA5q13.2
AcetaminophenApprovedMRPS564969
downregulated
Acetaminophen results in decreased expression of MRPS5 mRNA2q11.1
AcetaminophenApprovedMRPS751081
downregulated
Acetaminophen results in decreased expression of MRPS7 mRNA17q25.1
AcetaminophenApprovedMRPS964965
downregulated
Acetaminophen results in decreased expression of MRPS9 mRNA2q12.1
AcetaminophenApprovedMRS257380
downregulated
Acetaminophen results in decreased expression of MRS2 mRNA6p22.3
AcetaminophenApprovedMSRB3253827
downregulated
Acetaminophen results in decreased expression of MSRB3 mRNA12q14.3
AcetaminophenApprovedMTCH123787
upregulated
Acetaminophen results in increased expression of MTCH1 mRNA6p21.2
AcetaminophenApprovedMTERF280298
upregulated
Acetaminophen results in increased expression of MTERF2 mRNA12q23.3
AcetaminophenApprovedMTERF351001
upregulated
Acetaminophen results in increased expression of MTERF3 mRNA8q22.1
AcetaminophenApprovedMTFMT123263
upregulated
Acetaminophen results in increased expression of MTFMT mRNA15q22.31
AcetaminophenApprovedMTHFD1L25902
downregulated
Acetaminophen results in decreased expression of MTHFD1L mRNA6q25.1
AcetaminophenApprovedMTIF3219402
upregulated
Acetaminophen results in increased expression of MTIF3 mRNA13q12.2
AcetaminophenApprovedMTO125821
downregulated
Acetaminophen results in decreased expression of MTO1 mRNA6q13
AcetaminophenApprovedMTOR2475
upregulated
Acetaminophen results in increased expression of MTOR mRNA1p36.22
AcetaminophenApprovedMTPAP55149
downregulated
Acetaminophen results in decreased expression of MTPAP mRNA10p11.23
AcetaminophenApprovedMTRF19617
downregulated
Acetaminophen results in decreased expression of MTRF1 mRNA13q14.11
AcetaminophenApprovedMTRR4552
downregulated
Acetaminophen results in decreased expression of MTRR mRNA5p15.31
AcetaminophenApprovedMTX210651
upregulated
Acetaminophen results in increased expression of MTX2 mRNA2q31.1
AcetaminophenApprovedMTX3345778
downregulated
Acetaminophen results in decreased expression of MTX3 mRNA5q14.1
AcetaminophenApprovedNADK2133686
downregulated
Acetaminophen results in decreased expression of NADK2 mRNA5p13.2
AcetaminophenApprovedNAGS162417
downregulated
Acetaminophen results in decreased expression of NAGS mRNA17q21.31
AcetaminophenApprovedNARS279731
downregulated
Acetaminophen results in decreased expression of NARS2 mRNA11q14.1
AcetaminophenApprovedNDFIP254602
upregulated
Acetaminophen results in increased expression of NDFIP2 mRNA13q31.1
AcetaminophenApprovedNDUFA14694
downregulated
Acetaminophen results in decreased expression of NDUFA1 mRNAXq24
AcetaminophenApprovedNDUFA24695
upregulated
Acetaminophen results in increased expression of NDUFA2 mRNA5q31.3
AcetaminophenApprovedNDUFA74701
upregulated
Acetaminophen results in increased expression of NDUFA7 mRNA19p13.2
AcetaminophenApprovedNDUFA84702
upregulated
Acetaminophen results in increased expression of NDUFA8 mRNA9q33.2
AcetaminophenApprovedNDUFA94704
downregulated
Acetaminophen results in decreased expression of NDUFA9 mRNA12p13.3
AcetaminophenApprovedNDUFAF151103
upregulated
Acetaminophen results in increased expression of NDUFAF1 mRNA15q15.1
AcetaminophenApprovedNDUFAF429078
downregulated
Acetaminophen results in decreased expression of NDUFAF4 mRNA6q16.1
AcetaminophenApprovedNDUFAF579133
downregulated
Acetaminophen results in decreased expression of NDUFAF5 mRNA20p12.1
AcetaminophenApprovedNDUFAF6137682
downregulated
Acetaminophen results in decreased expression of NDUFAF6 mRNA8q22.1
AcetaminophenApprovedNDUFAF755471
downregulated
Acetaminophen results in decreased expression of NDUFAF7 mRNA2p22.2
AcetaminophenApprovedNDUFB14707
upregulated
Acetaminophen results in increased expression of NDUFB1 mRNA14q31.3
AcetaminophenApprovedNDUFB104716
downregulated
Acetaminophen results in decreased expression of NDUFB10 mRNA16p13.3
AcetaminophenApprovedNDUFB24708
upregulated
Acetaminophen results in increased expression of NDUFB2 mRNA7q34
AcetaminophenApprovedNDUFB34709
upregulated
Acetaminophen results in increased expression of NDUFB3 mRNA2q33.1
AcetaminophenApprovedNDUFB54711
upregulated
Acetaminophen results in increased expression of NDUFB5 mRNA3q26.33
AcetaminophenApprovedNDUFB74713
downregulated
Acetaminophen results in decreased expression of NDUFB7 mRNA19p13.12
AcetaminophenApprovedNDUFB94715
downregulated
Acetaminophen results in decreased expression of NDUFB9 mRNA8q24.13
AcetaminophenApprovedNDUFC14717
downregulated
Acetaminophen results in decreased expression of NDUFC1 mRNA4q31.1
AcetaminophenApprovedNDUFC24718
downregulated
Acetaminophen results in decreased expression of NDUFC2 mRNA11q14.1
AcetaminophenApprovedNDUFS14719
downregulated
Acetaminophen results in decreased expression of NDUFS1 mRNA2q33.3
AcetaminophenApprovedNDUFS24720
downregulated
Acetaminophen results in decreased expression of NDUFS2 mRNA1q23.3
AcetaminophenApprovedNDUFS64726
downregulated
Acetaminophen results in decreased expression of NDUFS6 mRNA5p15.33
AcetaminophenApprovedNDUFS84728
downregulated
Acetaminophen results in decreased expression of NDUFS8 mRNA11q13.2
AcetaminophenApprovedNDUFV34731
upregulated
Acetaminophen results in increased expression of NDUFV3 mRNA21q22.3
AcetaminophenApprovedNEK991754
upregulated
Acetaminophen results in increased expression of NEK9 mRNA14q24.3
AcetaminophenApprovedNELFE7936
upregulated
Acetaminophen results in increased expression of NELFE mRNA6p21.33
AcetaminophenApprovedNIPSNAP18508
downregulated
Acetaminophen results in decreased expression of NIPSNAP1 mRNA22q12.2
AcetaminophenApprovedNLN57486
downregulated
Acetaminophen results in decreased expression of NLN mRNA5q12.3
AcetaminophenApprovedNMNAT3349565
upregulated
Acetaminophen results in increased expression of NMNAT3 mRNA3q23
AcetaminophenApprovedNOA184273
upregulated
Acetaminophen results in increased expression of NOA1 mRNA4q12
AcetaminophenApprovedNR3C12908
downregulated
Acetaminophen results in decreased expression of NR3C1 mRNA5q31.3
AcetaminophenApprovedNSD354904
downregulated
Acetaminophen results in decreased expression of NSD3 mRNA8p11.23
AcetaminophenApprovedNTHL14913
downregulated
Acetaminophen results in decreased expression of NTHL1 mRNA16p13.3
AcetaminophenApprovedOAT4942
upregulated
Acetaminophen results in increased expression of OAT mRNA10q26.13
AcetaminophenApprovedOGDH4967
upregulated
Acetaminophen results in increased expression of OGDH mRNA7p13
AcetaminophenApprovedOGDHL55753
upregulated
Acetaminophen results in increased expression of OGDHL mRNA10q11.23
AcetaminophenApprovedOGG14968
upregulated
Acetaminophen results in increased expression of OGG1 mRNA3p25.3
AcetaminophenApprovedOPA14976
downregulated
Acetaminophen results in decreased expression of OPA1 mRNA3q29
AcetaminophenApprovedOXA1L5018
upregulated
Acetaminophen results in increased expression of OXA1L mRNA14q11.2
AcetaminophenApprovedOXCT15019
downregulated
Acetaminophen results in decreased expression of OXCT1 mRNA5p13.1
AcetaminophenApprovedOXR155074
upregulated
Acetaminophen results in increased expression of OXR1 mRNA8q23.1
AcetaminophenApprovedOXSM54995
downregulated
Acetaminophen results in decreased expression of OXSM mRNA3p24.2
AcetaminophenApprovedP4HA15033
downregulated
Acetaminophen results in decreased expression of P4HA1 mRNA10q22.1
AcetaminophenApprovedPABPN18106
downregulated
Acetaminophen results in decreased expression of PABPN1 mRNA14q11.2
AcetaminophenApprovedPACS223241
upregulated
Acetaminophen results in increased expression of PACS2 mRNA14q32.33
AcetaminophenApprovedPANK280025
upregulated
Acetaminophen results in increased expression of PANK2 mRNA20p13
AcetaminophenApprovedPARK711315
upregulated
Acetaminophen results in increased expression of PARK7 mRNA1p36.23
AcetaminophenApprovedPARL55486
downregulated
Acetaminophen results in decreased expression of PARL mRNA3q27.1
AcetaminophenApprovedPARS225973
upregulated
Acetaminophen results in increased expression of PARS2 mRNA1p32.3
AcetaminophenApprovedPCCA5095
downregulated
Acetaminophen results in decreased expression of PCCA mRNA13q32.3
AcetaminophenApprovedPCCB5096
downregulated
Acetaminophen results in decreased expression of PCCB mRNA3q22.3
AcetaminophenApprovedPCLAF9768
upregulated
Acetaminophen results in increased expression of PCLAF mRNA15q22.31
AcetaminophenApprovedPDHA15160
downregulated
Acetaminophen results in decreased expression of PDHA1 mRNAXp22.12
AcetaminophenApprovedPDHX8050
downregulated
Acetaminophen results in decreased expression of PDHX mRNA11p13
AcetaminophenApprovedPDK15163
downregulated
Acetaminophen results in decreased expression of PDK1 mRNA2q31.1
AcetaminophenApprovedPDK25164
downregulated
Acetaminophen results in decreased expression of PDK2 mRNA17q21.33
AcetaminophenApprovedPDK35165
upregulated
Acetaminophen results in increased expression of PDK3 mRNAXp22.11
AcetaminophenApprovedPDP154704
upregulated
Acetaminophen results in increased expression of PDP1 mRNA8q22.1
AcetaminophenApprovedPEBP15037
downregulated
Acetaminophen results in decreased expression of PEBP1 mRNA12q24.23
AcetaminophenApprovedPECR55825
downregulated
Acetaminophen results in decreased expression of PECR mRNA2q35
AcetaminophenApprovedPEMT10400
downregulated
Acetaminophen results in decreased expression of PEMT mRNA17p11.2
AcetaminophenApprovedPERP64065
upregulated
Acetaminophen results in increased expression of PERP mRNA6q23.3
AcetaminophenApprovedPEX11B8799
upregulated
Acetaminophen results in increased expression of PEX11B mRNA1q21.1
AcetaminophenApprovedPHB5245
downregulated
Acetaminophen results in decreased expression of PHB mRNA17q21.33
AcetaminophenApprovedPHB211331
downregulated
Acetaminophen results in decreased expression of PHB2 mRNA12p13.31
AcetaminophenApprovedPHYKPL85007
downregulated
Acetaminophen results in decreased expression of PHYKPL mRNA5q35.3
AcetaminophenApprovedPINK165018
upregulated
Acetaminophen results in increased expression of PINK1 mRNA1p36.12
AcetaminophenApprovedPITRM110531
upregulated
Acetaminophen results in increased expression of PITRM1 mRNA10p15.2
AcetaminophenApprovedPMAIP15366
upregulated
Acetaminophen results in increased expression of PMAIP1 mRNA18q21.32
AcetaminophenApprovedPMPCB9512
downregulated
Acetaminophen results in decreased expression of PMPCB mRNA7q22.1
AcetaminophenApprovedPNPT187178
downregulated
Acetaminophen results in decreased expression of PNPT1 mRNA2p16.1
AcetaminophenApprovedPOLDIP226073
downregulated
Acetaminophen results in decreased expression of POLDIP2 mRNA17q11.2
AcetaminophenApprovedPOLG5428
upregulated
Acetaminophen results in increased expression of POLG mRNA15q26.1
AcetaminophenApprovedPPA227068
downregulated
Acetaminophen results in decreased expression of PPA2 mRNA4q24
AcetaminophenApprovedPPIF10105
downregulated
Acetaminophen results in decreased expression of PPIF mRNA10q22.3
AcetaminophenApprovedPPL5493
upregulated
Acetaminophen results in increased expression of PPL mRNA16p13.3
AcetaminophenApprovedPPM1K152926
upregulated
Acetaminophen results in increased expression of PPM1K mRNA4q22.1
AcetaminophenApprovedPPP3CA5530
upregulated
Acetaminophen results in increased expression of PPP3CA mRNA4q24
AcetaminophenApprovedPPP3CB5532
upregulated
Acetaminophen results in increased expression of PPP3CB mRNA10q22.2
AcetaminophenApprovedPRDX15052
upregulated
Acetaminophen results in increased expression of PRDX1 mRNA1p34.1
AcetaminophenApprovedPRDX410549
downregulated
Acetaminophen results in decreased expression of PRDX4 mRNAXp22.11
AcetaminophenApprovedPRDX525824
downregulated
Acetaminophen results in decreased expression of PRDX5 mRNA11q13.1
AcetaminophenApprovedPRELID127166
downregulated
Acetaminophen results in decreased expression of PRELID1 mRNA5q35.3
AcetaminophenApprovedPRKACA5566
upregulated
Acetaminophen results in increased expression of PRKACA mRNA19p13.1
AcetaminophenApprovedPRKCA5578
upregulated
Acetaminophen results in increased expression of PRKCA mRNA17q24.2
AcetaminophenApprovedPSAP5660
upregulated
Acetaminophen results in increased expression of PSAP mRNA10q22.1
AcetaminophenApprovedPSEN15663
upregulated
Acetaminophen results in increased expression of PSEN1 mRNA14q24.2
AcetaminophenApprovedPSMA65687
downregulated
Acetaminophen results in decreased expression of PSMA6 mRNA14q13.2
AcetaminophenApprovedPSMC45704
downregulated
Acetaminophen results in decreased expression of PSMC4 mRNA19q13.11-q13.13
AcetaminophenApprovedPTCD355037
downregulated
Acetaminophen results in decreased expression of PTCD3 mRNA2p11.2
AcetaminophenApprovedPYCR15831
downregulated
Acetaminophen results in decreased expression of PYCR1 mRNA17q25.3
AcetaminophenApprovedPYURF100996939
downregulated
Acetaminophen results in decreased expression of PYURF mRNA4q22.1
AcetaminophenApprovedQTRT181890
downregulated
Acetaminophen results in decreased expression of QTRT1 mRNA19p13.3
AcetaminophenApprovedRAB3210981
upregulated
Acetaminophen results in increased expression of RAB32 mRNA6q24.3
AcetaminophenApprovedRAF15894
downregulated
Acetaminophen results in decreased expression of RAF1 mRNA3p25.2
AcetaminophenApprovedRALGAPA1253959
downregulated
Acetaminophen results in decreased expression of RALGAPA1 mRNA14q13.2
AcetaminophenApprovedRARS257038
downregulated
Acetaminophen results in decreased expression of RARS2 mRNA6q15
AcetaminophenApprovedREEP165055
upregulated
Acetaminophen results in increased expression of REEP1 mRNA2p11.2
AcetaminophenApprovedREXO225996
downregulated
Acetaminophen results in decreased expression of REXO2 mRNA11q23.2
AcetaminophenApprovedRHOT155288
upregulated
Acetaminophen results in increased expression of RHOT1 mRNA17q11.2
AcetaminophenApprovedRIPK18737
upregulated
Acetaminophen results in increased expression of RIPK1 mRNA6p25.2
AcetaminophenApprovedRMDN355177
upregulated
Acetaminophen results in increased expression of RMDN3 mRNA15q15.1
AcetaminophenApprovedRSAD155316
upregulated
Acetaminophen results in increased expression of RSAD1 mRNA17q21.33
AcetaminophenApprovedRTN4IP184816
upregulated
Acetaminophen results in increased expression of RTN4IP1 mRNA6q21
AcetaminophenApprovedSARDH1757
downregulated
Acetaminophen results in decreased expression of SARDH mRNA9q34.2
AcetaminophenApprovedSARS254938
downregulated
Acetaminophen results in decreased expression of SARS2 mRNA19q13.2
AcetaminophenApprovedSCO16341
downregulated
Acetaminophen results in decreased expression of SCO1 mRNA17p13.1
AcetaminophenApprovedSCO29997
downregulated
Acetaminophen results in decreased expression of SCO2 mRNA22q13.33
AcetaminophenApprovedSFXN2118980
downregulated
Acetaminophen results in decreased expression of SFXN2 mRNA10q24.32
AcetaminophenApprovedSFXN381855
downregulated
Acetaminophen results in decreased expression of SFXN3 mRNA10q24.31
AcetaminophenApprovedSFXN4119559
downregulated
Acetaminophen results in decreased expression of SFXN4 mRNA10q26.11
AcetaminophenApprovedSH3BP59467
upregulated
Acetaminophen results in increased expression of SH3BP5 mRNA3p25.1
AcetaminophenApprovedSH3GLB151100
upregulated
Acetaminophen results in increased expression of SH3GLB1 mRNA1p22.3
AcetaminophenApprovedSHC16464
downregulated
Acetaminophen results in decreased expression of SHC1 mRNA1q21.3
AcetaminophenApprovedSHMT26472
downregulated
Acetaminophen results in decreased expression of SHMT2 mRNA12q12-q14
AcetaminophenApprovedSIRT423409
upregulated
Acetaminophen results in increased expression of SIRT4 mRNA12q24.31
AcetaminophenApprovedSIRT751547
upregulated
Acetaminophen results in increased expression of SIRT7 mRNA17q25.3
AcetaminophenApprovedSLC25A16576
upregulated
Acetaminophen results in increased expression of SLC25A1 mRNA22q11.21
AcetaminophenApprovedSLC25A118402
upregulated
Acetaminophen results in increased expression of SLC25A11 mRNA17p13.2
AcetaminophenApprovedSLC25A1310165
downregulated
Acetaminophen results in decreased expression of SLC25A13 mRNA7q21.3
AcetaminophenApprovedSLC25A149016
upregulated
Acetaminophen results in increased expression of SLC25A14 mRNAXq26.1
AcetaminophenApprovedSLC25A1510166
downregulated
Acetaminophen results in decreased expression of SLC25A15 mRNA13q14.11
AcetaminophenApprovedSLC25A168034
upregulated
Acetaminophen results in increased expression of SLC25A16 mRNA10q21.3
AcetaminophenApprovedSLC25A1960386
upregulated
Acetaminophen results in increased expression of SLC25A19 mRNA17q25.1
AcetaminophenApprovedSLC25A2279751
upregulated
Acetaminophen results in increased expression of SLC25A22 mRNA11p15.5
AcetaminophenApprovedSLC25A2379085
upregulated
Acetaminophen results in increased expression of SLC25A23 mRNA19p13.3
AcetaminophenApprovedSLC25A2881894
upregulated
Acetaminophen results in increased expression of SLC25A28 mRNA10q24.2
AcetaminophenApprovedSLC25A29123096
upregulated
Acetaminophen results in increased expression of SLC25A29 mRNA14q32.2
AcetaminophenApprovedSLC25A30253512
downregulated
Acetaminophen results in decreased expression of SLC25A30 mRNA13q14.13
AcetaminophenApprovedSLC25A3281034
downregulated
Acetaminophen results in decreased expression of SLC25A32 mRNA8q22.3
AcetaminophenApprovedSLC25A3384275
downregulated
Acetaminophen results in decreased expression of SLC25A33 mRNA1p36.22
AcetaminophenApprovedSLC25A3655186
downregulated
Acetaminophen results in decreased expression of SLC25A36 mRNA3q23
AcetaminophenApprovedSLC25A3854977
downregulated
Acetaminophen results in decreased expression of SLC25A38 mRNA3p22.1
AcetaminophenApprovedSLC25A3951629
upregulated
Acetaminophen results in increased expression of SLC25A39 mRNA17q21.31
AcetaminophenApprovedSLC25A4291
upregulated
Acetaminophen results in increased expression of SLC25A4 mRNA4q35.1
AcetaminophenApprovedSLC25A4055972
upregulated
Acetaminophen results in increased expression of SLC25A40 mRNA7q21.12
AcetaminophenApprovedSLC25A43203427
downregulated
Acetaminophen results in decreased expression of SLC25A43 mRNAXq24
AcetaminophenApprovedSLC25A449673
upregulated
Acetaminophen results in increased expression of SLC25A44 mRNA1q22
AcetaminophenApprovedSLC25A45283130
upregulated
Acetaminophen results in increased expression of SLC25A45 mRNA11q13.1
AcetaminophenApprovedSLC25A47283600
downregulated
Acetaminophen results in decreased expression of SLC25A47 mRNA14q32.2
AcetaminophenApprovedSLC25A5292
upregulated
Acetaminophen results in increased expression of SLC25A5 mRNAXq24
AcetaminophenApprovedSLC25A5192014
upregulated
Acetaminophen results in increased expression of SLC25A51 mRNA9p13.2-p13.1
AcetaminophenApprovedSLC25A6293
downregulated
Acetaminophen results in decreased expression of SLC25A6 mRNAXp22.32 and Yp11.3
AcetaminophenApprovedSLC35B351000
upregulated
Acetaminophen results in increased expression of SLC35B3 mRNA6p24.3
AcetaminophenApprovedSLC9A610479
upregulated
Acetaminophen results in increased expression of SLC9A6 mRNAXq26.3
AcetaminophenApprovedSLC9B2133308
downregulated
Acetaminophen results in decreased expression of SLC9B2 mRNA4q24
AcetaminophenApprovedSMDT191689
downregulated
Acetaminophen results in decreased expression of SMDT1 mRNA22q13.2
AcetaminophenApprovedSOD16647
upregulated
Acetaminophen results in increased expression of SOD1 mRNA21q22.11
AcetaminophenApprovedSPG76687
upregulated
Acetaminophen results in increased expression of SPG7 mRNA16q24.3
AcetaminophenApprovedSRGAP223380
upregulated
Acetaminophen results in increased expression of SRGAP2 mRNA1q32.1
AcetaminophenApprovedSSBP16742
downregulated
Acetaminophen results in decreased expression of SSBP1 mRNA7q34
AcetaminophenApprovedSTARD1390627
downregulated
Acetaminophen results in decreased expression of STARD13 mRNA13q13.1
AcetaminophenApprovedSTOML230968
downregulated
Acetaminophen results in decreased expression of STOML2 mRNA9p13.3
AcetaminophenApprovedSTXBP16812
upregulated
Acetaminophen results in increased expression of STXBP1 mRNA9q34.11
AcetaminophenApprovedSUCLG28801
downregulated
Acetaminophen results in decreased expression of SUCLG2 mRNA3p14.1
AcetaminophenApprovedSUOX6821
upregulated
Acetaminophen results in increased expression of SUOX mRNA12q13.2
AcetaminophenApprovedSUPV3L16832
downregulated
Acetaminophen results in decreased expression of SUPV3L1 mRNA10q22.1
AcetaminophenApprovedSURF16834
upregulated
Acetaminophen results in increased expression of SURF1 mRNA9q34.2
AcetaminophenApprovedSYNJ28871
downregulated
Acetaminophen results in decreased expression of SYNJ2 mRNA6q25.3
AcetaminophenApprovedTAMM41132001
downregulated
Acetaminophen results in decreased expression of TAMM41 mRNA3p25.2
AcetaminophenApprovedTAOK351347
upregulated
Acetaminophen results in increased expression of TAOK3 mRNA12q
AcetaminophenApprovedTARS280222
downregulated
Acetaminophen results in decreased expression of TARS2 mRNA1q21.2
AcetaminophenApprovedTAT6898
downregulated
Acetaminophen results in decreased expression of TAT mRNA16q22.2
AcetaminophenApprovedTAZ6901
upregulated
Acetaminophen results in increased expression of TAZ mRNAXq28
AcetaminophenApprovedTCAIM285343
downregulated
Acetaminophen results in decreased expression of TCAIM mRNA3p21.31
AcetaminophenApprovedTFAM7019
downregulated
Acetaminophen results in decreased expression of TFAM mRNA10q21.1
AcetaminophenApprovedTFB1M51106
downregulated
Acetaminophen results in decreased expression of TFB1M mRNA6q25.3
AcetaminophenApprovedTFB2M64216
downregulated
Acetaminophen results in decreased expression of TFB2M mRNA1q44
AcetaminophenApprovedTFRC7037
upregulated
Acetaminophen results in increased expression of TFRC mRNA3q29
AcetaminophenApprovedTGM27052
upregulated
Acetaminophen results in increased expression of TGM2 mRNA20q11.23
AcetaminophenApprovedTIMM1026519
downregulated
Acetaminophen results in decreased expression of TIMM10 mRNA11q12.1
AcetaminophenApprovedTIMM10B26515
downregulated
Acetaminophen results in decreased expression of TIMM10B mRNA11p15.4
AcetaminophenApprovedTIMM4410469
downregulated
Acetaminophen results in decreased expression of TIMM44 mRNA19p13.2
AcetaminophenApprovedTIMM926520
downregulated
Acetaminophen results in decreased expression of TIMM9 mRNA14q23.1
AcetaminophenApprovedTIMMDC151300
upregulated
Acetaminophen results in increased expression of TIMMDC1 mRNA3q13.33
AcetaminophenApprovedTMEM14355260
upregulated
Acetaminophen results in increased expression of TMEM143 mRNA19q13.32
AcetaminophenApprovedTMEM256254863
upregulated
Acetaminophen results in increased expression of TMEM256 mRNA17p13.1
AcetaminophenApprovedTMEM8B51754
upregulated
Acetaminophen results in increased expression of TMEM8B mRNA9p13.3
AcetaminophenApprovedTMX456255
upregulated
Acetaminophen results in increased expression of TMX4 mRNA20p12.3
AcetaminophenApprovedTOMM209804
downregulated
Acetaminophen results in decreased expression of TOMM20 mRNA1q42.3
AcetaminophenApprovedTOMM2256993
downregulated
Acetaminophen results in decreased expression of TOMM22 mRNA22q13.1
AcetaminophenApprovedTOMM3410953
upregulated
Acetaminophen results in increased expression of TOMM34 mRNA20q13.12
AcetaminophenApprovedTOMM40L84134
downregulated
Acetaminophen results in decreased expression of TOMM40L mRNA1q23.3
AcetaminophenApprovedTOMM5401505
downregulated
Acetaminophen results in decreased expression of TOMM5 mRNA9p13.2
AcetaminophenApprovedTOMM709868
downregulated
Acetaminophen results in decreased expression of TOMM70 mRNA3q12.2
AcetaminophenApprovedTP537157
downregulated
Acetaminophen results in decreased expression of TP53 mRNA17p13.1
AcetaminophenApprovedTPP11200
upregulated
Acetaminophen results in increased expression of TPP1 mRNA11p15.4
AcetaminophenApprovedTRAP110131
downregulated
Acetaminophen results in decreased expression of TRAP1 mRNA16p13.3
AcetaminophenApprovedTRIT154802
downregulated
Acetaminophen results in decreased expression of TRIT1 mRNA1p34.2
AcetaminophenApprovedTRMT10C54931
downregulated
Acetaminophen results in decreased expression of TRMT10C mRNA3q12.3
AcetaminophenApprovedTRMU55687
downregulated
Acetaminophen results in decreased expression of TRMU mRNA22q13.31
AcetaminophenApprovedTRNT151095
downregulated
Acetaminophen results in decreased expression of TRNT1 mRNA3p26.2
AcetaminophenApprovedTSFM10102
downregulated
Acetaminophen results in decreased expression of TSFM mRNA12q14.1
AcetaminophenApprovedTST7263
upregulated
Acetaminophen results in increased expression of TST mRNA22q12.3
AcetaminophenApprovedTWNK56652
downregulated
Acetaminophen results in decreased expression of TWNK mRNA10q24.31
AcetaminophenApprovedTXN225828
upregulated
Acetaminophen results in increased expression of TXN2 mRNA22q12.3
AcetaminophenApprovedTXNDC1251060
upregulated
Acetaminophen results in increased expression of TXNDC12 mRNA1p32.3
AcetaminophenApprovedUCP27351
upregulated
Acetaminophen results in increased expression of UCP2 mRNA11q13
AcetaminophenApprovedUQCR1029796
downregulated
Acetaminophen results in decreased expression of UQCR10 mRNA22q12.2
AcetaminophenApprovedUROS7390
upregulated
Acetaminophen results in increased expression of UROS mRNA10q26.2
AcetaminophenApprovedUSP3084749
downregulated
Acetaminophen results in decreased expression of USP30 mRNA12q24.11
AcetaminophenApprovedVAMP16843
upregulated
Acetaminophen results in increased expression of VAMP1 mRNA12p13.31
AcetaminophenApprovedVARS7407
downregulated
Acetaminophen results in decreased expression of VARS mRNA6p21.33
AcetaminophenApprovedVARS257176
downregulated
Acetaminophen results in decreased expression of VARS2 mRNA6p21.33
AcetaminophenApprovedVDAC37419
upregulated
Acetaminophen results in increased expression of VDAC3 mRNA8p11.21
AcetaminophenApprovedWARS210352
downregulated
Acetaminophen results in decreased expression of WARS2 mRNA1p12
AcetaminophenApprovedXAF154739
downregulated
Acetaminophen results in decreased expression of XAF1 mRNA17p13.2
AcetaminophenApprovedXPNPEP363929
upregulated
Acetaminophen results in increased expression of XPNPEP3 mRNA22q13.2
AcetaminophenApprovedYARS251067
downregulated
Acetaminophen results in decreased expression of YARS2 mRNA12p11.21
AcetaminophenApprovedYME1L110730
downregulated
Acetaminophen results in decreased expression of YME1L1 mRNA10p12.1
AcetaminophenApprovedYRDC79693
downregulated
Acetaminophen results in decreased expression of YRDC mRNA1p34.3
AcetaminophenApprovedZFHX3463
downregulated
Acetaminophen results in decreased expression of ZFHX3 mRNA16q22.2-q22.3