Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.
Article Details
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Jiang J, Briede JJ, Jennen DG, Van Summeren A, Saritas-Brauers K, Schaart G, Kleinjans JC, de Kok TM
Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.
Toxicol Lett. 2015 Apr 16;234(2):139-50. doi: 10.1016/j.toxlet.2015.02.012. Epub 2015 Feb 19.
- PubMed ID
- 25704631 [ View in PubMed]
- Abstract
Acetaminophen (APAP) overdosage results in hepatotoxicity, but the underlying molecular mechanisms are still not completely understood. In the current study, we focused on mitochondrial-specific oxidative liver injury induced by APAP exposure. Owning to genetic polymorphisms in the CYP2E1 gene or varying inducibility by xenobiotics, the CYP2E1 mRNA level and protein activity vary extensively among individuals. As CYP2E1 is a known ROS generating enzyme, we chose HepG2 to minimize CYP2E1-induced ROS formation, which will help us better understand the APAP induced mitochondrial-specific hepatotoxicity in a subpopulation with low CYP2E1 activity. HepG2 cells were exposed to a low and toxic dose (0.5 and 10mM) of APAP and analyzed at four time points for genome-wide gene expression. Mitochondria were isolated and electron spin resonance spectroscopy was performed to measure the formation of mitochondrial ROS. The yield of ATP was measured to confirm the impact of the toxic dose of APAP on cellular energy production. Our results indicate that 10mM APAP significantly influences the expression of mitochondrial protein-encoding genes in association with an increase in mitochondrial ROS formation. Additionally, 10mM APAP affects the expression of genes encoding the subunits of electron transport chain (ETC) complexes, which may alter normal mitochondrial functions by disrupting the assembly, stability, and structural integrity of ETC complexes, leading to a measurable depletion of ATP, and cell death. The expression of mitochondrium-specific antioxidant enzyme, SOD2, is reduced which may limit the ROS scavenging ability and cause imbalance of the mitochondrial ROS homeostasis. Overall, transcriptome analysis reveals the molecular processes involved in the observed APAP-induced increase of mitochondrial ROS formation and the associated APAP-induced oxidative stress.
DrugBank Data that Cites this Article
- Pharmaco-transcriptomics
Drug Drug Groups Gene Gene ID Change Interaction Chromosome Acetaminophen Approved AADAT 51166 downregulated Acetaminophen results in decreased expression of AADAT mRNA 4q33 Acetaminophen Approved ABAT 18 upregulated Acetaminophen results in increased expression of ABAT mRNA 16p13.2 Acetaminophen Approved ABCB10 23456 upregulated Acetaminophen results in increased expression of ABCB10 mRNA 1q42.13 Acetaminophen Approved ABCE1 6059 downregulated Acetaminophen results in decreased expression of ABCE1 mRNA 4q31.21 Acetaminophen Approved ACAD8 27034 upregulated Acetaminophen results in increased expression of ACAD8 mRNA 11q25 Acetaminophen Approved ACADSB 36 downregulated Acetaminophen results in decreased expression of ACADSB mRNA 10q26.13 Acetaminophen Approved ACADVL 37 upregulated Acetaminophen results in increased expression of ACADVL mRNA 17p13.1 Acetaminophen Approved ACAT1 38 downregulated Acetaminophen results in decreased expression of ACAT1 mRNA 11q22.3 Acetaminophen Approved ACBD3 64746 downregulated Acetaminophen results in decreased expression of ACBD3 mRNA 1q42.12 Acetaminophen Approved ACO2 50 upregulated Acetaminophen results in increased expression of ACO2 mRNA 22q13.2 Acetaminophen Approved ACOT13 55856 upregulated Acetaminophen results in increased expression of ACOT13 mRNA 6p22.3 Acetaminophen Approved ACOT7 11332 upregulated Acetaminophen results in increased expression of ACOT7 mRNA 1p36.31 Acetaminophen Approved ACP6 51205 downregulated Acetaminophen results in decreased expression of ACP6 mRNA 1q21.2 Acetaminophen Approved ACSF2 80221 upregulated Acetaminophen results in increased expression of ACSF2 mRNA 17q21.33 Acetaminophen Approved ACSL1 2180 upregulated Acetaminophen results in increased expression of ACSL1 mRNA 4q35.1 Acetaminophen Approved ACSL5 51703 downregulated Acetaminophen results in decreased expression of ACSL5 mRNA 10q25.2 Acetaminophen Approved ACSM3 6296 downregulated Acetaminophen results in decreased expression of ACSM3 mRNA 16p12.3 Acetaminophen Approved ACSM5 54988 downregulated Acetaminophen results in decreased expression of ACSM5 mRNA 16p12.3 Acetaminophen Approved ACSS1 84532 downregulated Acetaminophen results in decreased expression of ACSS1 mRNA 20p11.21 Acetaminophen Approved ADH5 128 downregulated Acetaminophen results in decreased expression of ADH5 mRNA 4q23 Acetaminophen Approved AFG3L2 10939 upregulated Acetaminophen results in increased expression of AFG3L2 mRNA 18p11.21 Acetaminophen Approved AGK 55750 upregulated Acetaminophen results in increased expression of AGK mRNA 7q34 Acetaminophen Approved AGMAT 79814 downregulated Acetaminophen results in decreased expression of AGMAT mRNA 1p36.21 Acetaminophen Approved AGPAT5 55326 downregulated Acetaminophen results in decreased expression of AGPAT5 mRNA 8p23.1 Acetaminophen Approved AGPS 8540 downregulated Acetaminophen results in decreased expression of AGPS mRNA 2q31.2 Acetaminophen Approved AGXT 189 downregulated Acetaminophen results in decreased expression of AGXT mRNA 2q37.3 Acetaminophen Approved AIFM1 9131 downregulated Acetaminophen results in decreased expression of AIFM1 mRNA Xq26.1 Acetaminophen Approved AIFM2 84883 downregulated Acetaminophen results in decreased expression of AIFM2 mRNA 10q22.1 Acetaminophen Approved AK2 204 downregulated Acetaminophen results in decreased expression of AK2 mRNA 1p35.1 Acetaminophen Approved AK4 205 downregulated Acetaminophen results in decreased expression of AK4 mRNA 1p31.3 Acetaminophen Approved AKAP1 8165 downregulated Acetaminophen results in decreased expression of AKAP1 mRNA 17q22 Acetaminophen Approved AKR7A2 8574 upregulated Acetaminophen results in increased expression of AKR7A2 mRNA 1p36.13 Acetaminophen Approved ALDH18A1 5832 downregulated Acetaminophen results in decreased expression of ALDH18A1 mRNA 10q24.1 Acetaminophen Approved ALDH1B1 219 downregulated Acetaminophen results in decreased expression of ALDH1B1 mRNA 9p13.1 Acetaminophen Approved ALDH2 217 downregulated Acetaminophen results in decreased expression of ALDH2 mRNA 12q24.12 Acetaminophen Approved ALDH3A2 224 downregulated Acetaminophen results in decreased expression of ALDH3A2 mRNA 17p11.2 Acetaminophen Approved ALDH6A1 4329 downregulated Acetaminophen results in decreased expression of ALDH6A1 mRNA 14q24.3 Acetaminophen Approved AMT 275 downregulated Acetaminophen results in decreased expression of AMT mRNA 3p21.31 Acetaminophen Approved APEX2 27301 upregulated Acetaminophen results in increased expression of APEX2 mRNA Xp11.21 Acetaminophen Approved ARAF 369 upregulated Acetaminophen results in increased expression of ARAF mRNA Xp11.3 Acetaminophen Approved ARL2BP 23568 upregulated Acetaminophen results in increased expression of ARL2BP mRNA 16q13 Acetaminophen Approved ARSB 411 downregulated Acetaminophen results in decreased expression of ARSB mRNA 5q14.1 Acetaminophen Approved ATP5B 506 downregulated Acetaminophen results in decreased expression of ATP5B mRNA 12q13.3 Acetaminophen Approved ATP5D 513 downregulated Acetaminophen results in decreased expression of ATP5D mRNA 19p13.3 Acetaminophen Approved ATP5E 514 downregulated Acetaminophen results in decreased expression of ATP5E mRNA 20q13.32 Acetaminophen Approved ATP5I 521 downregulated Acetaminophen results in decreased expression of ATP5I mRNA 4p16.3 Acetaminophen Approved ATP5L 10632 upregulated Acetaminophen results in increased expression of ATP5L mRNA 11q23.3 Acetaminophen Approved ATP5S 27109 upregulated Acetaminophen results in increased expression of ATP5S mRNA 14q21.3 Acetaminophen Approved ATP6V1E1 529 upregulated Acetaminophen results in increased expression of ATP6V1E1 mRNA 22q11.21 Acetaminophen Approved ATP7B 540 downregulated Acetaminophen results in decreased expression of ATP7B mRNA 13q14.3 Acetaminophen Approved ATPAF2 91647 upregulated Acetaminophen results in increased expression of ATPAF2 mRNA 17p11.2 Acetaminophen Approved ATPIF1 93974 downregulated Acetaminophen results in decreased expression of ATPIF1 mRNA 1p35.3 Acetaminophen Approved AUH 549 downregulated Acetaminophen results in decreased expression of AUH mRNA 9q22.31 Acetaminophen Approved AZIN2 113451 upregulated Acetaminophen results in increased expression of AZIN2 mRNA 1p35.1 Acetaminophen Approved BAD 572 upregulated Acetaminophen results in increased expression of BAD mRNA 11q13.1 Acetaminophen Approved BCL2L11 10018 upregulated Acetaminophen results in increased expression of BCL2L11 mRNA 2q13 Acetaminophen Approved BCL2L13 23786 upregulated Acetaminophen results in increased expression of BCL2L13 mRNA 22q11.21 Acetaminophen Approved BDH1 622 downregulated Acetaminophen results in decreased expression of BDH1 mRNA 3q29 Acetaminophen Approved BID 637 downregulated Acetaminophen results in decreased expression of BID mRNA 22q11.21 Acetaminophen Approved BIK 638 upregulated Acetaminophen results in increased expression of BIK mRNA 22q13.2 Acetaminophen Approved BNIP3 664 downregulated Acetaminophen results in decreased expression of BNIP3 mRNA 10q26.3 Acetaminophen Approved BNIP3L 665 downregulated Acetaminophen results in decreased expression of BNIP3L mRNA 8p21.2 Acetaminophen Approved BPHL 670 upregulated Acetaminophen results in increased expression of BPHL mRNA 6p25.2 Acetaminophen Approved BRD8 10902 upregulated Acetaminophen results in increased expression of BRD8 mRNA 5q31.2 Acetaminophen Approved C1QBP 708 downregulated Acetaminophen results in decreased expression of C1QBP mRNA 17p13.2 Acetaminophen Approved CA5A 763 downregulated Acetaminophen results in decreased expression of CA5A mRNA 16q24.2 Acetaminophen Approved CAPRIN2 65981 upregulated Acetaminophen results in increased expression of CAPRIN2 mRNA 12p11.21 Acetaminophen Approved CARS2 79587 downregulated Acetaminophen results in decreased expression of CARS2 mRNA 13q34 Acetaminophen Approved CCDC90B 60492 upregulated Acetaminophen results in increased expression of CCDC90B mRNA 11q14.1 Acetaminophen Approved CEP89 84902 upregulated Acetaminophen results in increased expression of CEP89 mRNA 19q13.11 Acetaminophen Approved CHAF1B 8208 upregulated Acetaminophen results in increased expression of CHAF1B mRNA 21q22.12-q22.13 Acetaminophen Approved CHDH 55349 downregulated Acetaminophen results in decreased expression of CHDH mRNA 3p21.1 Acetaminophen Approved CISD1 55847 downregulated Acetaminophen results in decreased expression of CISD1 mRNA 10q21.1 Acetaminophen Approved CKMT2 1160 downregulated Acetaminophen results in decreased expression of CKMT2 mRNA 5q14.1 Acetaminophen Approved CLN3 1201 downregulated Acetaminophen results in decreased expression of CLN3 mRNA 16p12.1 Acetaminophen Approved CLPP 8192 downregulated Acetaminophen results in decreased expression of CLPP mRNA 19p13.3 Acetaminophen Approved CLPX 10845 downregulated Acetaminophen results in decreased expression of CLPX mRNA 15q22.31 Acetaminophen Approved CLU 1191 upregulated Acetaminophen results in increased expression of CLU mRNA 8p21.1 Acetaminophen Approved CLYBL 171425 upregulated Acetaminophen results in increased expression of CLYBL mRNA 13q32.3 Acetaminophen Approved COA3 28958 downregulated Acetaminophen results in decreased expression of COA3 mRNA 17q21.2 Acetaminophen Approved COA6 388753 downregulated Acetaminophen results in decreased expression of COA6 mRNA 1q42.2 Acetaminophen Approved COG8 84342 downregulated Acetaminophen results in decreased expression of COG8 mRNA 16q22.1 Acetaminophen Approved COL4A3BP 10087 downregulated Acetaminophen results in decreased expression of COL4A3BP mRNA 5q13.3 Acetaminophen Approved COQ10A 93058 upregulated Acetaminophen results in increased expression of COQ10A mRNA 12q13.3 Acetaminophen Approved COQ2 27235 upregulated Acetaminophen results in increased expression of COQ2 mRNA 4q21.23 Acetaminophen Approved COQ3 51805 downregulated Acetaminophen results in decreased expression of COQ3 mRNA 6q16.2 Acetaminophen Approved COQ4 51117 downregulated Acetaminophen results in decreased expression of COQ4 mRNA 9q34.11 Acetaminophen Approved COQ5 84274 upregulated Acetaminophen results in increased expression of COQ5 mRNA 12q24.31 Acetaminophen Approved COQ8A 56997 downregulated Acetaminophen results in decreased expression of COQ8A mRNA 1q42.13 Acetaminophen Approved COX10 1352 downregulated Acetaminophen results in decreased expression of COX10 mRNA 17p12 Acetaminophen Approved COX11 1353 downregulated Acetaminophen results in decreased expression of COX11 mRNA 17q22 Acetaminophen Approved COX15 1355 upregulated Acetaminophen results in increased expression of COX15 mRNA 10q24.2 Acetaminophen Approved COX5A 9377 downregulated Acetaminophen results in decreased expression of COX5A mRNA 15q24.2 Acetaminophen Approved COX6B1 1340 upregulated Acetaminophen results in increased expression of COX6B1 mRNA 19q13.12 Acetaminophen Approved COX6C 1345 upregulated Acetaminophen results in increased expression of COX6C mRNA 8q22.2 Acetaminophen Approved COX7A2 1347 upregulated Acetaminophen results in increased expression of COX7A2 mRNA 6q14.1 Acetaminophen Approved COX7A2L 9167 upregulated Acetaminophen results in increased expression of COX7A2L mRNA 2p21 Acetaminophen Approved COX7B 1349 upregulated Acetaminophen results in increased expression of COX7B mRNA Xq21.1 Acetaminophen Approved COX8A 1351 upregulated Acetaminophen results in increased expression of COX8A mRNA 11q13.1 Acetaminophen Approved CPOX 1371 upregulated Acetaminophen results in increased expression of CPOX mRNA 3q11.2 Acetaminophen Approved CPS1 1373 downregulated Acetaminophen results in decreased expression of CPS1 mRNA 2q34 Acetaminophen Approved CRLS1 54675 downregulated Acetaminophen results in decreased expression of CRLS1 mRNA 20p12.3 Acetaminophen Approved CRY1 1407 upregulated Acetaminophen results in increased expression of CRY1 mRNA 12q23.3 Acetaminophen Approved CSDE1 7812 downregulated Acetaminophen results in decreased expression of CSDE1 mRNA 1p13.2 Acetaminophen Approved CTSA 5476 upregulated Acetaminophen results in increased expression of CTSA mRNA 20q13.12 Acetaminophen Approved CTSB 1508 upregulated Acetaminophen results in increased expression of CTSB mRNA 8p23.1 Acetaminophen Approved CYB5A 1528 downregulated Acetaminophen results in decreased expression of CYB5A mRNA 18q22.3 Acetaminophen Approved CYB5B 80777 downregulated Acetaminophen results in decreased expression of CYB5B mRNA 16q22.1 Acetaminophen Approved CYBA 1535 upregulated Acetaminophen results in increased expression of CYBA mRNA 16q24.2 Acetaminophen Approved CYC1 1537 downregulated Acetaminophen results in decreased expression of CYC1 mRNA 8q24.3 Acetaminophen Approved CYCS 54205 upregulated Acetaminophen results in increased expression of CYCS mRNA 7p15.3 Acetaminophen Approved CYP1A1 1543 upregulated Acetaminophen results in increased expression of CYP1A1 mRNA 15q24.1 Acetaminophen Approved CYP27A1 1593 downregulated Acetaminophen results in decreased expression of CYP27A1 mRNA 2q35 Acetaminophen Approved CYP27B1 1594 downregulated Acetaminophen results in decreased expression of CYP27B1 mRNA 12q14.1 Acetaminophen Approved DAP3 7818 downregulated Acetaminophen results in decreased expression of DAP3 mRNA 1q22 Acetaminophen Approved DECR1 1666 downregulated Acetaminophen results in decreased expression of DECR1 mRNA 8q21.3 Acetaminophen Approved DGUOK 1716 downregulated Acetaminophen results in decreased expression of DGUOK mRNA 2p13.1 Acetaminophen Approved DHODH 1723 downregulated Acetaminophen results in decreased expression of DHODH mRNA 16q22.2 Acetaminophen Approved DHRS1 115817 downregulated Acetaminophen results in decreased expression of DHRS1 mRNA 14q12 Acetaminophen Approved DHRS2 10202 upregulated Acetaminophen results in increased expression of DHRS2 mRNA 14q11.2 Acetaminophen Approved DHTKD1 55526 upregulated Acetaminophen results in increased expression of DHTKD1 mRNA 10p14 Acetaminophen Approved DHX30 22907 downregulated Acetaminophen results in decreased expression of DHX30 mRNA 3p21.31 Acetaminophen Approved DIABLO 56616 upregulated Acetaminophen results in increased expression of DIABLO mRNA 12q24.31 Acetaminophen Approved DLAT 1737 downregulated Acetaminophen results in decreased expression of DLAT mRNA 11q23.1 Acetaminophen Approved DNA2 1763 upregulated Acetaminophen results in increased expression of DNA2 mRNA 10q21.3 Acetaminophen Approved DNAJA3 9093 downregulated Acetaminophen results in decreased expression of DNAJA3 mRNA 16p13.3 Acetaminophen Approved DNAJC11 55735 downregulated Acetaminophen results in decreased expression of DNAJC11 mRNA 1p36.31 Acetaminophen Approved DNAJC19 131118 downregulated Acetaminophen results in decreased expression of DNAJC19 mRNA 3q26.33 Acetaminophen Approved DNM1L 10059 upregulated Acetaminophen results in increased expression of DNM1L mRNA 12p11.21 Acetaminophen Approved DPYSL2 1808 upregulated Acetaminophen results in increased expression of DPYSL2 mRNA 8p21.2 Acetaminophen Approved DTD1 92675 downregulated Acetaminophen results in decreased expression of DTD1 mRNA 20p11.23 Acetaminophen Approved E2F1 1869 upregulated Acetaminophen results in increased expression of E2F1 mRNA 20q11.22 Acetaminophen Approved EARS2 124454 downregulated Acetaminophen results in decreased expression of EARS2 mRNA 16p12.2 Acetaminophen Approved ECH1 1891 downregulated Acetaminophen results in decreased expression of ECH1 mRNA 19q13.2 Acetaminophen Approved ECHDC2 55268 downregulated Acetaminophen results in decreased expression of ECHDC2 mRNA 1p32.3 Acetaminophen Approved ECI2 10455 downregulated Acetaminophen results in decreased expression of ECI2 mRNA 6p25.2 Acetaminophen Approved EHHADH 1962 downregulated Acetaminophen results in decreased expression of EHHADH mRNA 3q27.2 Acetaminophen Approved ELOVL6 79071 downregulated Acetaminophen results in decreased expression of ELOVL6 mRNA 4q25 Acetaminophen Approved EMC8 10328 downregulated Acetaminophen results in decreased expression of EMC8 mRNA 16q24.1 Acetaminophen Approved ENDOG 2021 downregulated Acetaminophen results in decreased expression of ENDOG mRNA 9q34.11 Acetaminophen Approved ENOSF1 55556 downregulated Acetaminophen results in decreased expression of ENOSF1 mRNA 18p11.32 Acetaminophen Approved ETFB 2109 downregulated Acetaminophen results in decreased expression of ETFB mRNA 19q13.41 Acetaminophen Approved ETFDH 2110 upregulated Acetaminophen results in increased expression of ETFDH mRNA 4q32.1 Acetaminophen Approved FAHD1 81889 downregulated Acetaminophen results in decreased expression of FAHD1 mRNA 16p13.3 Acetaminophen Approved FAM110B 90362 downregulated Acetaminophen results in decreased expression of FAM110B mRNA 8q12.1 Acetaminophen Approved FAM136A 84908 downregulated Acetaminophen results in decreased expression of FAM136A mRNA 2p13.3 Acetaminophen Approved FDXR 2232 upregulated Acetaminophen results in increased expression of FDXR mRNA 17q25.1 Acetaminophen Approved FECH 2235 upregulated Acetaminophen results in increased expression of FECH mRNA 18q21.31 Acetaminophen Approved FEN1 2237 upregulated Acetaminophen results in increased expression of FEN1 mRNA 11q12.2 Acetaminophen Approved FIS1 51024 downregulated Acetaminophen results in decreased expression of FIS1 mRNA 7q22.1 Acetaminophen Approved FPGS 2356 downregulated Acetaminophen results in decreased expression of FPGS mRNA 9q34.11 Acetaminophen Approved FRMD6 122786 upregulated Acetaminophen results in increased expression of FRMD6 mRNA 14q22.1 Acetaminophen Approved FXN 2395 downregulated Acetaminophen results in decreased expression of FXN mRNA 9q21.11 Acetaminophen Approved GATB 5188 downregulated Acetaminophen results in decreased expression of GATB mRNA 4q31.3 Acetaminophen Approved GATM 2628 downregulated Acetaminophen results in decreased expression of GATM mRNA 15q21.1 Acetaminophen Approved GCAT 23464 upregulated Acetaminophen results in increased expression of GCAT mRNA 22q13.1 Acetaminophen Approved GCDH 2639 upregulated Acetaminophen results in increased expression of GCDH mRNA 19p13.13 Acetaminophen Approved GFER 2671 downregulated Acetaminophen results in decreased expression of GFER mRNA 16p13.3 Acetaminophen Approved GLDC 2731 downregulated Acetaminophen results in decreased expression of GLDC mRNA 9p24.1 Acetaminophen Approved GLOD4 51031 downregulated Acetaminophen results in decreased expression of GLOD4 mRNA 17p13.3 Acetaminophen Approved GLS 2744 upregulated Acetaminophen results in increased expression of GLS mRNA 2q32.2 Acetaminophen Approved GLS2 27165 upregulated Acetaminophen results in increased expression of GLS2 mRNA 12q13.3 Acetaminophen Approved GLT8D1 55830 downregulated Acetaminophen results in decreased expression of GLT8D1 mRNA 3p21.1 Acetaminophen Approved GLUD2 2747 downregulated Acetaminophen results in decreased expression of GLUD2 mRNA Xq24 Acetaminophen Approved GLYCTK 132158 downregulated Acetaminophen results in decreased expression of GLYCTK mRNA 3p21.2 Acetaminophen Approved GM2A 2760 upregulated Acetaminophen results in increased expression of GM2A mRNA 5q33.1 Acetaminophen Approved GPAM 57678 downregulated Acetaminophen results in decreased expression of GPAM mRNA 10q25.2 Acetaminophen Approved GPRC5C 55890 downregulated Acetaminophen results in decreased expression of GPRC5C mRNA 17q25.1 Acetaminophen Approved GPX4 2879 upregulated Acetaminophen results in increased expression of GPX4 mRNA 19p13.3 Acetaminophen Approved GRN 2896 upregulated Acetaminophen results in increased expression of GRN mRNA 17q21.31 Acetaminophen Approved GRPEL1 80273 downregulated Acetaminophen results in decreased expression of GRPEL1 mRNA 4p16.1 Acetaminophen Approved GRPEL2 134266 downregulated Acetaminophen results in decreased expression of GRPEL2 mRNA 5q32 Acetaminophen Approved GSTK1 373156 upregulated Acetaminophen results in increased expression of GSTK1 mRNA 7q34 Acetaminophen Approved GSTZ1 2954 upregulated Acetaminophen results in increased expression of GSTZ1 mRNA 14q24.3 Acetaminophen Approved GTF3C2 2976 downregulated Acetaminophen results in decreased expression of GTF3C2 mRNA 2p23.3 Acetaminophen Approved HAGH 3029 upregulated Acetaminophen results in increased expression of HAGH mRNA 16p13.3 Acetaminophen Approved HARS2 23438 downregulated Acetaminophen results in decreased expression of HARS2 mRNA 5q31.3 Acetaminophen Approved HEBP1 50865 upregulated Acetaminophen results in increased expression of HEBP1 mRNA 12p13.1 Acetaminophen Approved HEBP2 23593 downregulated Acetaminophen results in decreased expression of HEBP2 mRNA 6q24.1 Acetaminophen Approved HIBADH 11112 upregulated Acetaminophen results in increased expression of HIBADH mRNA 7p15.2 Acetaminophen Approved HINT2 84681 upregulated Acetaminophen results in increased expression of HINT2 mRNA 9p13.3 Acetaminophen Approved HK1 3098 upregulated Acetaminophen results in increased expression of HK1 mRNA 10q22.1 Acetaminophen Approved HKDC1 80201 downregulated Acetaminophen results in decreased expression of HKDC1 mRNA 10q22.1 Acetaminophen Approved HMBS 3145 upregulated Acetaminophen results in increased expression of HMBS mRNA 11q23.3 Acetaminophen Approved HMGCL 3155 upregulated Acetaminophen results in increased expression of HMGCL mRNA 1p36.11 Acetaminophen Approved HSD17B10 3028 downregulated Acetaminophen results in decreased expression of HSD17B10 mRNA Xp11.22 Acetaminophen Approved HSD17B4 3295 downregulated Acetaminophen results in decreased expression of HSD17B4 mRNA 5q23.1 Acetaminophen Approved HSPA1A 3303 upregulated Acetaminophen results in increased expression of HSPA1A mRNA 6p21.33 Acetaminophen Approved HSPA1B 3304 upregulated Acetaminophen results in increased expression of HSPA1B mRNA 6p21.33 Acetaminophen Approved HSPA9 3313 downregulated Acetaminophen results in decreased expression of HSPA9 mRNA 5q31.2 Acetaminophen Approved HSPE1 3336 downregulated Acetaminophen results in decreased expression of HSPE1 mRNA 2q33.1 Acetaminophen Approved HTRA2 27429 upregulated Acetaminophen results in increased expression of HTRA2 mRNA 2p13.1 Acetaminophen Approved IARS2 55699 downregulated Acetaminophen results in decreased expression of IARS2 mRNA 1q41 Acetaminophen Approved IDH2 3418 upregulated Acetaminophen results in increased expression of IDH2 mRNA 15q26.1 Acetaminophen Approved IDH3A 3419 upregulated Acetaminophen results in increased expression of IDH3A mRNA 15q25.1 Acetaminophen Approved IDH3B 3420 downregulated Acetaminophen results in decreased expression of IDH3B mRNA 20p13 Acetaminophen Approved IFI6 2537 upregulated Acetaminophen results in increased expression of IFI6 mRNA 1p35.3 Acetaminophen Approved ILF3 3609 downregulated Acetaminophen results in decreased expression of ILF3 mRNA 19p13.2 Acetaminophen Approved IMMP1L 196294 downregulated Acetaminophen results in decreased expression of IMMP1L mRNA 11p13 Acetaminophen Approved IMMT 10989 upregulated Acetaminophen results in increased expression of IMMT mRNA 2p11.2 Acetaminophen Approved ISCA2 122961 upregulated Acetaminophen results in increased expression of ISCA2 mRNA 14q24.3 Acetaminophen Approved ISCU 23479 upregulated Acetaminophen results in increased expression of ISCU mRNA 12q23.3 Acetaminophen Approved ISOC2 79763 downregulated Acetaminophen results in decreased expression of ISOC2 mRNA 19q13.42 Acetaminophen Approved IVD 3712 downregulated Acetaminophen results in decreased expression of IVD mRNA 15q15.1 Acetaminophen Approved KARS 3735 downregulated Acetaminophen results in decreased expression of KARS mRNA 16q23.1 Acetaminophen Approved KIAA0391 9692 downregulated Acetaminophen results in decreased expression of KIAA0391 mRNA 14q13.2 Acetaminophen Approved KIF1BP 26128 upregulated Acetaminophen results in increased expression of KIF1BP mRNA 10q22.1 Acetaminophen Approved KYNU 8942 downregulated Acetaminophen results in decreased expression of KYNU mRNA 2q22.2 Acetaminophen Approved L2HGDH 79944 upregulated Acetaminophen results in increased expression of L2HGDH mRNA 14q21.3 Acetaminophen Approved LACTB 114294 upregulated Acetaminophen results in increased expression of LACTB mRNA 15q22.2 Acetaminophen Approved LAP3 51056 downregulated Acetaminophen results in decreased expression of LAP3 mRNA 4p15.32 Acetaminophen Approved LARS2 23395 downregulated Acetaminophen results in decreased expression of LARS2 mRNA 3p21.31 Acetaminophen Approved LDHD 197257 upregulated Acetaminophen results in increased expression of LDHD mRNA 16q23.1 Acetaminophen Approved LETM1 3954 downregulated Acetaminophen results in decreased expression of LETM1 mRNA 4p16.3 Acetaminophen Approved LIMK2 3985 upregulated Acetaminophen results in increased expression of LIMK2 mRNA 22q12.2 Acetaminophen Approved LONP1 9361 downregulated Acetaminophen results in decreased expression of LONP1 mRNA 19p13.2 Acetaminophen Approved LRRC59 55379 downregulated Acetaminophen results in decreased expression of LRRC59 mRNA 17q21.33 Acetaminophen Approved LYPLA1 10434 downregulated Acetaminophen results in decreased expression of LYPLA1 mRNA 8q11.23 Acetaminophen Approved LYRM4 57128 downregulated Acetaminophen results in decreased expression of LYRM4 mRNA 6p25.1 Acetaminophen Approved MAIP1 79568 downregulated Acetaminophen results in decreased expression of MAIP1 mRNA 2q33.1 Acetaminophen Approved MAOA 4128 downregulated Acetaminophen results in decreased expression of MAOA mRNA Xp11.3 Acetaminophen Approved MAOB 4129 downregulated Acetaminophen results in decreased expression of MAOB mRNA Xp11.3 Acetaminophen Approved MARC1 64757 downregulated Acetaminophen results in decreased expression of MARC1 mRNA 1q41 Acetaminophen Approved MARC2 54996 upregulated Acetaminophen results in increased expression of MARC2 mRNA 1q41 Acetaminophen Approved MCCC1 56922 downregulated Acetaminophen results in decreased expression of MCCC1 mRNA 3q27.1 Acetaminophen Approved MCCC2 64087 downregulated Acetaminophen results in decreased expression of MCCC2 mRNA 5q13.2 Acetaminophen Approved MCEE 84693 downregulated Acetaminophen results in decreased expression of MCEE mRNA 2p13.3 Acetaminophen Approved ME2 4200 upregulated Acetaminophen results in increased expression of ME2 mRNA 18q21.2 Acetaminophen Approved METAP1D 254042 downregulated Acetaminophen results in decreased expression of METAP1D mRNA 2q31.1 Acetaminophen Approved METTL12 751071 upregulated Acetaminophen results in increased expression of METTL12 mRNA 11q12.3 Acetaminophen Approved METTL17 64745 downregulated Acetaminophen results in decreased expression of METTL17 mRNA 14q11.2 Acetaminophen Approved MIEF1 54471 downregulated Acetaminophen results in decreased expression of MIEF1 mRNA 22q13.1 Acetaminophen Approved MIPEP 4285 upregulated Acetaminophen results in increased expression of MIPEP mRNA 13q12.12 Acetaminophen Approved MMADHC 27249 downregulated Acetaminophen results in decreased expression of MMADHC mRNA 2q23.2 Acetaminophen Approved MPC2 25874 downregulated Acetaminophen results in decreased expression of MPC2 mRNA 1q24.2 Acetaminophen Approved MPV17 4358 upregulated Acetaminophen results in increased expression of MPV17 mRNA 2p23.3 Acetaminophen Approved MRPL1 65008 downregulated Acetaminophen results in decreased expression of MRPL1 mRNA 4q21.1 Acetaminophen Approved MRPL10 124995 upregulated Acetaminophen results in increased expression of MRPL10 mRNA 17q21.32 Acetaminophen Approved MRPL11 65003 downregulated Acetaminophen results in decreased expression of MRPL11 mRNA 11q13.2 Acetaminophen Approved MRPL12 6182 downregulated Acetaminophen results in decreased expression of MRPL12 mRNA 17q25.3 Acetaminophen Approved MRPL15 29088 downregulated Acetaminophen results in decreased expression of MRPL15 mRNA 8q11.23 Acetaminophen Approved MRPL16 54948 downregulated Acetaminophen results in decreased expression of MRPL16 mRNA 11q12.1 Acetaminophen Approved MRPL19 9801 downregulated Acetaminophen results in decreased expression of MRPL19 mRNA 2p12 Acetaminophen Approved MRPL22 29093 downregulated Acetaminophen results in decreased expression of MRPL22 mRNA 5q33.2 Acetaminophen Approved MRPL23 6150 downregulated Acetaminophen results in decreased expression of MRPL23 mRNA 11p15.5 Acetaminophen Approved MRPL28 10573 downregulated Acetaminophen results in decreased expression of MRPL28 mRNA 16p13.3 Acetaminophen Approved MRPL3 11222 downregulated Acetaminophen results in decreased expression of MRPL3 mRNA 3q22.1 Acetaminophen Approved MRPL32 64983 downregulated Acetaminophen results in decreased expression of MRPL32 mRNA 7p14.1 Acetaminophen Approved MRPL34 64981 downregulated Acetaminophen results in decreased expression of MRPL34 mRNA 19p13.1 Acetaminophen Approved MRPL35 51318 downregulated Acetaminophen results in decreased expression of MRPL35 mRNA 2p11.2 Acetaminophen Approved MRPL39 54148 downregulated Acetaminophen results in decreased expression of MRPL39 mRNA 21q21.3 Acetaminophen Approved MRPL4 51073 downregulated Acetaminophen results in decreased expression of MRPL4 mRNA 19p13.2 Acetaminophen Approved MRPL40 64976 upregulated Acetaminophen results in increased expression of MRPL40 mRNA 22q11.21 Acetaminophen Approved MRPL41 64975 upregulated Acetaminophen results in increased expression of MRPL41 mRNA 9q34.3 Acetaminophen Approved MRPL43 84545 downregulated Acetaminophen results in decreased expression of MRPL43 mRNA 10q24.31 Acetaminophen Approved MRPL44 65080 downregulated Acetaminophen results in decreased expression of MRPL44 mRNA 2q36.1 Acetaminophen Approved MRPL46 26589 downregulated Acetaminophen results in decreased expression of MRPL46 mRNA 15q25.3 Acetaminophen Approved MRPL48 51642 downregulated Acetaminophen results in decreased expression of MRPL48 mRNA 11q13.4 Acetaminophen Approved MRPL50 54534 downregulated Acetaminophen results in decreased expression of MRPL50 mRNA 9q31.1 Acetaminophen Approved MRPL54 116541 downregulated Acetaminophen results in decreased expression of MRPL54 mRNA 19p13.3 Acetaminophen Approved MRPL9 65005 downregulated Acetaminophen results in decreased expression of MRPL9 mRNA 1q21.3 Acetaminophen Approved MRPS10 55173 upregulated Acetaminophen results in increased expression of MRPS10 mRNA 6p21.1 Acetaminophen Approved MRPS11 64963 upregulated Acetaminophen results in increased expression of MRPS11 mRNA 15q25.3 Acetaminophen Approved MRPS12 6183 downregulated Acetaminophen results in decreased expression of MRPS12 mRNA 19q13.2 Acetaminophen Approved MRPS15 64960 downregulated Acetaminophen results in decreased expression of MRPS15 mRNA 1p34.3 Acetaminophen Approved MRPS18B 28973 downregulated Acetaminophen results in decreased expression of MRPS18B mRNA 6p21.33 Acetaminophen Approved MRPS2 51116 downregulated Acetaminophen results in decreased expression of MRPS2 mRNA 9q34.3 Acetaminophen Approved MRPS21 54460 upregulated Acetaminophen results in increased expression of MRPS21 mRNA 1q21.2 Acetaminophen Approved MRPS23 51649 downregulated Acetaminophen results in decreased expression of MRPS23 mRNA 17q22 Acetaminophen Approved MRPS26 64949 downregulated Acetaminophen results in decreased expression of MRPS26 mRNA 20p13 Acetaminophen Approved MRPS27 23107 downregulated Acetaminophen results in decreased expression of MRPS27 mRNA 5q13.2 Acetaminophen Approved MRPS28 28957 downregulated Acetaminophen results in decreased expression of MRPS28 mRNA 8q21.13 Acetaminophen Approved MRPS30 10884 downregulated Acetaminophen results in decreased expression of MRPS30 mRNA 5p12 Acetaminophen Approved MRPS33 51650 upregulated Acetaminophen results in increased expression of MRPS33 mRNA 7q34 Acetaminophen Approved MRPS34 65993 downregulated Acetaminophen results in decreased expression of MRPS34 mRNA 16p13.3 Acetaminophen Approved MRPS35 60488 downregulated Acetaminophen results in decreased expression of MRPS35 mRNA 12p11.22 Acetaminophen Approved MRPS36 92259 downregulated Acetaminophen results in decreased expression of MRPS36 mRNA 5q13.2 Acetaminophen Approved MRPS5 64969 downregulated Acetaminophen results in decreased expression of MRPS5 mRNA 2q11.1 Acetaminophen Approved MRPS7 51081 downregulated Acetaminophen results in decreased expression of MRPS7 mRNA 17q25.1 Acetaminophen Approved MRPS9 64965 downregulated Acetaminophen results in decreased expression of MRPS9 mRNA 2q12.1 Acetaminophen Approved MRS2 57380 downregulated Acetaminophen results in decreased expression of MRS2 mRNA 6p22.3 Acetaminophen Approved MSRB3 253827 downregulated Acetaminophen results in decreased expression of MSRB3 mRNA 12q14.3 Acetaminophen Approved MTCH1 23787 upregulated Acetaminophen results in increased expression of MTCH1 mRNA 6p21.2 Acetaminophen Approved MTERF2 80298 upregulated Acetaminophen results in increased expression of MTERF2 mRNA 12q23.3 Acetaminophen Approved MTERF3 51001 upregulated Acetaminophen results in increased expression of MTERF3 mRNA 8q22.1 Acetaminophen Approved MTFMT 123263 upregulated Acetaminophen results in increased expression of MTFMT mRNA 15q22.31 Acetaminophen Approved MTHFD1L 25902 downregulated Acetaminophen results in decreased expression of MTHFD1L mRNA 6q25.1 Acetaminophen Approved MTIF3 219402 upregulated Acetaminophen results in increased expression of MTIF3 mRNA 13q12.2 Acetaminophen Approved MTO1 25821 downregulated Acetaminophen results in decreased expression of MTO1 mRNA 6q13 Acetaminophen Approved MTOR 2475 upregulated Acetaminophen results in increased expression of MTOR mRNA 1p36.22 Acetaminophen Approved MTPAP 55149 downregulated Acetaminophen results in decreased expression of MTPAP mRNA 10p11.23 Acetaminophen Approved MTRF1 9617 downregulated Acetaminophen results in decreased expression of MTRF1 mRNA 13q14.11 Acetaminophen Approved MTRR 4552 downregulated Acetaminophen results in decreased expression of MTRR mRNA 5p15.31 Acetaminophen Approved MTX2 10651 upregulated Acetaminophen results in increased expression of MTX2 mRNA 2q31.1 Acetaminophen Approved MTX3 345778 downregulated Acetaminophen results in decreased expression of MTX3 mRNA 5q14.1 Acetaminophen Approved NADK2 133686 downregulated Acetaminophen results in decreased expression of NADK2 mRNA 5p13.2 Acetaminophen Approved NAGS 162417 downregulated Acetaminophen results in decreased expression of NAGS mRNA 17q21.31 Acetaminophen Approved NARS2 79731 downregulated Acetaminophen results in decreased expression of NARS2 mRNA 11q14.1 Acetaminophen Approved NDFIP2 54602 upregulated Acetaminophen results in increased expression of NDFIP2 mRNA 13q31.1 Acetaminophen Approved NDUFA1 4694 downregulated Acetaminophen results in decreased expression of NDUFA1 mRNA Xq24 Acetaminophen Approved NDUFA2 4695 upregulated Acetaminophen results in increased expression of NDUFA2 mRNA 5q31.3 Acetaminophen Approved NDUFA7 4701 upregulated Acetaminophen results in increased expression of NDUFA7 mRNA 19p13.2 Acetaminophen Approved NDUFA8 4702 upregulated Acetaminophen results in increased expression of NDUFA8 mRNA 9q33.2 Acetaminophen Approved NDUFA9 4704 downregulated Acetaminophen results in decreased expression of NDUFA9 mRNA 12p13.3 Acetaminophen Approved NDUFAF1 51103 upregulated Acetaminophen results in increased expression of NDUFAF1 mRNA 15q15.1 Acetaminophen Approved NDUFAF4 29078 downregulated Acetaminophen results in decreased expression of NDUFAF4 mRNA 6q16.1 Acetaminophen Approved NDUFAF5 79133 downregulated Acetaminophen results in decreased expression of NDUFAF5 mRNA 20p12.1 Acetaminophen Approved NDUFAF6 137682 downregulated Acetaminophen results in decreased expression of NDUFAF6 mRNA 8q22.1 Acetaminophen Approved NDUFAF7 55471 downregulated Acetaminophen results in decreased expression of NDUFAF7 mRNA 2p22.2 Acetaminophen Approved NDUFB1 4707 upregulated Acetaminophen results in increased expression of NDUFB1 mRNA 14q31.3 Acetaminophen Approved NDUFB10 4716 downregulated Acetaminophen results in decreased expression of NDUFB10 mRNA 16p13.3 Acetaminophen Approved NDUFB2 4708 upregulated Acetaminophen results in increased expression of NDUFB2 mRNA 7q34 Acetaminophen Approved NDUFB3 4709 upregulated Acetaminophen results in increased expression of NDUFB3 mRNA 2q33.1 Acetaminophen Approved NDUFB5 4711 upregulated Acetaminophen results in increased expression of NDUFB5 mRNA 3q26.33 Acetaminophen Approved NDUFB7 4713 downregulated Acetaminophen results in decreased expression of NDUFB7 mRNA 19p13.12 Acetaminophen Approved NDUFB9 4715 downregulated Acetaminophen results in decreased expression of NDUFB9 mRNA 8q24.13 Acetaminophen Approved NDUFC1 4717 downregulated Acetaminophen results in decreased expression of NDUFC1 mRNA 4q31.1 Acetaminophen Approved NDUFC2 4718 downregulated Acetaminophen results in decreased expression of NDUFC2 mRNA 11q14.1 Acetaminophen Approved NDUFS1 4719 downregulated Acetaminophen results in decreased expression of NDUFS1 mRNA 2q33.3 Acetaminophen Approved NDUFS2 4720 downregulated Acetaminophen results in decreased expression of NDUFS2 mRNA 1q23.3 Acetaminophen Approved NDUFS6 4726 downregulated Acetaminophen results in decreased expression of NDUFS6 mRNA 5p15.33 Acetaminophen Approved NDUFS8 4728 downregulated Acetaminophen results in decreased expression of NDUFS8 mRNA 11q13.2 Acetaminophen Approved NDUFV3 4731 upregulated Acetaminophen results in increased expression of NDUFV3 mRNA 21q22.3 Acetaminophen Approved NEK9 91754 upregulated Acetaminophen results in increased expression of NEK9 mRNA 14q24.3 Acetaminophen Approved NELFE 7936 upregulated Acetaminophen results in increased expression of NELFE mRNA 6p21.33 Acetaminophen Approved NIPSNAP1 8508 downregulated Acetaminophen results in decreased expression of NIPSNAP1 mRNA 22q12.2 Acetaminophen Approved NLN 57486 downregulated Acetaminophen results in decreased expression of NLN mRNA 5q12.3 Acetaminophen Approved NMNAT3 349565 upregulated Acetaminophen results in increased expression of NMNAT3 mRNA 3q23 Acetaminophen Approved NOA1 84273 upregulated Acetaminophen results in increased expression of NOA1 mRNA 4q12 Acetaminophen Approved NR3C1 2908 downregulated Acetaminophen results in decreased expression of NR3C1 mRNA 5q31.3 Acetaminophen Approved NSD3 54904 downregulated Acetaminophen results in decreased expression of NSD3 mRNA 8p11.23 Acetaminophen Approved NTHL1 4913 downregulated Acetaminophen results in decreased expression of NTHL1 mRNA 16p13.3 Acetaminophen Approved OAT 4942 upregulated Acetaminophen results in increased expression of OAT mRNA 10q26.13 Acetaminophen Approved OGDH 4967 upregulated Acetaminophen results in increased expression of OGDH mRNA 7p13 Acetaminophen Approved OGDHL 55753 upregulated Acetaminophen results in increased expression of OGDHL mRNA 10q11.23 Acetaminophen Approved OGG1 4968 upregulated Acetaminophen results in increased expression of OGG1 mRNA 3p25.3 Acetaminophen Approved OPA1 4976 downregulated Acetaminophen results in decreased expression of OPA1 mRNA 3q29 Acetaminophen Approved OXA1L 5018 upregulated Acetaminophen results in increased expression of OXA1L mRNA 14q11.2 Acetaminophen Approved OXCT1 5019 downregulated Acetaminophen results in decreased expression of OXCT1 mRNA 5p13.1 Acetaminophen Approved OXR1 55074 upregulated Acetaminophen results in increased expression of OXR1 mRNA 8q23.1 Acetaminophen Approved OXSM 54995 downregulated Acetaminophen results in decreased expression of OXSM mRNA 3p24.2 Acetaminophen Approved P4HA1 5033 downregulated Acetaminophen results in decreased expression of P4HA1 mRNA 10q22.1 Acetaminophen Approved PABPN1 8106 downregulated Acetaminophen results in decreased expression of PABPN1 mRNA 14q11.2 Acetaminophen Approved PACS2 23241 upregulated Acetaminophen results in increased expression of PACS2 mRNA 14q32.33 Acetaminophen Approved PANK2 80025 upregulated Acetaminophen results in increased expression of PANK2 mRNA 20p13 Acetaminophen Approved PARK7 11315 upregulated Acetaminophen results in increased expression of PARK7 mRNA 1p36.23 Acetaminophen Approved PARL 55486 downregulated Acetaminophen results in decreased expression of PARL mRNA 3q27.1 Acetaminophen Approved PARS2 25973 upregulated Acetaminophen results in increased expression of PARS2 mRNA 1p32.3 Acetaminophen Approved PCCA 5095 downregulated Acetaminophen results in decreased expression of PCCA mRNA 13q32.3 Acetaminophen Approved PCCB 5096 downregulated Acetaminophen results in decreased expression of PCCB mRNA 3q22.3 Acetaminophen Approved PCLAF 9768 upregulated Acetaminophen results in increased expression of PCLAF mRNA 15q22.31 Acetaminophen Approved PDHA1 5160 downregulated Acetaminophen results in decreased expression of PDHA1 mRNA Xp22.12 Acetaminophen Approved PDHX 8050 downregulated Acetaminophen results in decreased expression of PDHX mRNA 11p13 Acetaminophen Approved PDK1 5163 downregulated Acetaminophen results in decreased expression of PDK1 mRNA 2q31.1 Acetaminophen Approved PDK2 5164 downregulated Acetaminophen results in decreased expression of PDK2 mRNA 17q21.33 Acetaminophen Approved PDK3 5165 upregulated Acetaminophen results in increased expression of PDK3 mRNA Xp22.11 Acetaminophen Approved PDP1 54704 upregulated Acetaminophen results in increased expression of PDP1 mRNA 8q22.1 Acetaminophen Approved PEBP1 5037 downregulated Acetaminophen results in decreased expression of PEBP1 mRNA 12q24.23 Acetaminophen Approved PECR 55825 downregulated Acetaminophen results in decreased expression of PECR mRNA 2q35 Acetaminophen Approved PEMT 10400 downregulated Acetaminophen results in decreased expression of PEMT mRNA 17p11.2 Acetaminophen Approved PERP 64065 upregulated Acetaminophen results in increased expression of PERP mRNA 6q23.3 Acetaminophen Approved PEX11B 8799 upregulated Acetaminophen results in increased expression of PEX11B mRNA 1q21.1 Acetaminophen Approved PHB 5245 downregulated Acetaminophen results in decreased expression of PHB mRNA 17q21.33 Acetaminophen Approved PHB2 11331 downregulated Acetaminophen results in decreased expression of PHB2 mRNA 12p13.31 Acetaminophen Approved PHYKPL 85007 downregulated Acetaminophen results in decreased expression of PHYKPL mRNA 5q35.3 Acetaminophen Approved PINK1 65018 upregulated Acetaminophen results in increased expression of PINK1 mRNA 1p36.12 Acetaminophen Approved PITRM1 10531 upregulated Acetaminophen results in increased expression of PITRM1 mRNA 10p15.2 Acetaminophen Approved PMAIP1 5366 upregulated Acetaminophen results in increased expression of PMAIP1 mRNA 18q21.32 Acetaminophen Approved PMPCB 9512 downregulated Acetaminophen results in decreased expression of PMPCB mRNA 7q22.1 Acetaminophen Approved PNPT1 87178 downregulated Acetaminophen results in decreased expression of PNPT1 mRNA 2p16.1 Acetaminophen Approved POLDIP2 26073 downregulated Acetaminophen results in decreased expression of POLDIP2 mRNA 17q11.2 Acetaminophen Approved POLG 5428 upregulated Acetaminophen results in increased expression of POLG mRNA 15q26.1 Acetaminophen Approved PPA2 27068 downregulated Acetaminophen results in decreased expression of PPA2 mRNA 4q24 Acetaminophen Approved PPIF 10105 downregulated Acetaminophen results in decreased expression of PPIF mRNA 10q22.3 Acetaminophen Approved PPL 5493 upregulated Acetaminophen results in increased expression of PPL mRNA 16p13.3 Acetaminophen Approved PPM1K 152926 upregulated Acetaminophen results in increased expression of PPM1K mRNA 4q22.1 Acetaminophen Approved PPP3CA 5530 upregulated Acetaminophen results in increased expression of PPP3CA mRNA 4q24 Acetaminophen Approved PPP3CB 5532 upregulated Acetaminophen results in increased expression of PPP3CB mRNA 10q22.2 Acetaminophen Approved PRDX1 5052 upregulated Acetaminophen results in increased expression of PRDX1 mRNA 1p34.1 Acetaminophen Approved PRDX4 10549 downregulated Acetaminophen results in decreased expression of PRDX4 mRNA Xp22.11 Acetaminophen Approved PRDX5 25824 downregulated Acetaminophen results in decreased expression of PRDX5 mRNA 11q13.1 Acetaminophen Approved PRELID1 27166 downregulated Acetaminophen results in decreased expression of PRELID1 mRNA 5q35.3 Acetaminophen Approved PRKACA 5566 upregulated Acetaminophen results in increased expression of PRKACA mRNA 19p13.1 Acetaminophen Approved PRKCA 5578 upregulated Acetaminophen results in increased expression of PRKCA mRNA 17q24.2 Acetaminophen Approved PSAP 5660 upregulated Acetaminophen results in increased expression of PSAP mRNA 10q22.1 Acetaminophen Approved PSEN1 5663 upregulated Acetaminophen results in increased expression of PSEN1 mRNA 14q24.2 Acetaminophen Approved PSMA6 5687 downregulated Acetaminophen results in decreased expression of PSMA6 mRNA 14q13.2 Acetaminophen Approved PSMC4 5704 downregulated Acetaminophen results in decreased expression of PSMC4 mRNA 19q13.11-q13.13 Acetaminophen Approved PTCD3 55037 downregulated Acetaminophen results in decreased expression of PTCD3 mRNA 2p11.2 Acetaminophen Approved PYCR1 5831 downregulated Acetaminophen results in decreased expression of PYCR1 mRNA 17q25.3 Acetaminophen Approved PYURF 100996939 downregulated Acetaminophen results in decreased expression of PYURF mRNA 4q22.1 Acetaminophen Approved QTRT1 81890 downregulated Acetaminophen results in decreased expression of QTRT1 mRNA 19p13.3 Acetaminophen Approved RAB32 10981 upregulated Acetaminophen results in increased expression of RAB32 mRNA 6q24.3 Acetaminophen Approved RAF1 5894 downregulated Acetaminophen results in decreased expression of RAF1 mRNA 3p25.2 Acetaminophen Approved RALGAPA1 253959 downregulated Acetaminophen results in decreased expression of RALGAPA1 mRNA 14q13.2 Acetaminophen Approved RARS2 57038 downregulated Acetaminophen results in decreased expression of RARS2 mRNA 6q15 Acetaminophen Approved REEP1 65055 upregulated Acetaminophen results in increased expression of REEP1 mRNA 2p11.2 Acetaminophen Approved REXO2 25996 downregulated Acetaminophen results in decreased expression of REXO2 mRNA 11q23.2 Acetaminophen Approved RHOT1 55288 upregulated Acetaminophen results in increased expression of RHOT1 mRNA 17q11.2 Acetaminophen Approved RIPK1 8737 upregulated Acetaminophen results in increased expression of RIPK1 mRNA 6p25.2 Acetaminophen Approved RMDN3 55177 upregulated Acetaminophen results in increased expression of RMDN3 mRNA 15q15.1 Acetaminophen Approved RSAD1 55316 upregulated Acetaminophen results in increased expression of RSAD1 mRNA 17q21.33 Acetaminophen Approved RTN4IP1 84816 upregulated Acetaminophen results in increased expression of RTN4IP1 mRNA 6q21 Acetaminophen Approved SARDH 1757 downregulated Acetaminophen results in decreased expression of SARDH mRNA 9q34.2 Acetaminophen Approved SARS2 54938 downregulated Acetaminophen results in decreased expression of SARS2 mRNA 19q13.2 Acetaminophen Approved SCO1 6341 downregulated Acetaminophen results in decreased expression of SCO1 mRNA 17p13.1 Acetaminophen Approved SCO2 9997 downregulated Acetaminophen results in decreased expression of SCO2 mRNA 22q13.33 Acetaminophen Approved SFXN2 118980 downregulated Acetaminophen results in decreased expression of SFXN2 mRNA 10q24.32 Acetaminophen Approved SFXN3 81855 downregulated Acetaminophen results in decreased expression of SFXN3 mRNA 10q24.31 Acetaminophen Approved SFXN4 119559 downregulated Acetaminophen results in decreased expression of SFXN4 mRNA 10q26.11 Acetaminophen Approved SH3BP5 9467 upregulated Acetaminophen results in increased expression of SH3BP5 mRNA 3p25.1 Acetaminophen Approved SH3GLB1 51100 upregulated Acetaminophen results in increased expression of SH3GLB1 mRNA 1p22.3 Acetaminophen Approved SHC1 6464 downregulated Acetaminophen results in decreased expression of SHC1 mRNA 1q21.3 Acetaminophen Approved SHMT2 6472 downregulated Acetaminophen results in decreased expression of SHMT2 mRNA 12q12-q14 Acetaminophen Approved SIRT4 23409 upregulated Acetaminophen results in increased expression of SIRT4 mRNA 12q24.31 Acetaminophen Approved SIRT7 51547 upregulated Acetaminophen results in increased expression of SIRT7 mRNA 17q25.3 Acetaminophen Approved SLC25A1 6576 upregulated Acetaminophen results in increased expression of SLC25A1 mRNA 22q11.21 Acetaminophen Approved SLC25A11 8402 upregulated Acetaminophen results in increased expression of SLC25A11 mRNA 17p13.2 Acetaminophen Approved SLC25A13 10165 downregulated Acetaminophen results in decreased expression of SLC25A13 mRNA 7q21.3 Acetaminophen Approved SLC25A14 9016 upregulated Acetaminophen results in increased expression of SLC25A14 mRNA Xq26.1 Acetaminophen Approved SLC25A15 10166 downregulated Acetaminophen results in decreased expression of SLC25A15 mRNA 13q14.11 Acetaminophen Approved SLC25A16 8034 upregulated Acetaminophen results in increased expression of SLC25A16 mRNA 10q21.3 Acetaminophen Approved SLC25A19 60386 upregulated Acetaminophen results in increased expression of SLC25A19 mRNA 17q25.1 Acetaminophen Approved SLC25A22 79751 upregulated Acetaminophen results in increased expression of SLC25A22 mRNA 11p15.5 Acetaminophen Approved SLC25A23 79085 upregulated Acetaminophen results in increased expression of SLC25A23 mRNA 19p13.3 Acetaminophen Approved SLC25A28 81894 upregulated Acetaminophen results in increased expression of SLC25A28 mRNA 10q24.2 Acetaminophen Approved SLC25A29 123096 upregulated Acetaminophen results in increased expression of SLC25A29 mRNA 14q32.2 Acetaminophen Approved SLC25A30 253512 downregulated Acetaminophen results in decreased expression of SLC25A30 mRNA 13q14.13 Acetaminophen Approved SLC25A32 81034 downregulated Acetaminophen results in decreased expression of SLC25A32 mRNA 8q22.3 Acetaminophen Approved SLC25A33 84275 downregulated Acetaminophen results in decreased expression of SLC25A33 mRNA 1p36.22 Acetaminophen Approved SLC25A36 55186 downregulated Acetaminophen results in decreased expression of SLC25A36 mRNA 3q23 Acetaminophen Approved SLC25A38 54977 downregulated Acetaminophen results in decreased expression of SLC25A38 mRNA 3p22.1 Acetaminophen Approved SLC25A39 51629 upregulated Acetaminophen results in increased expression of SLC25A39 mRNA 17q21.31 Acetaminophen Approved SLC25A4 291 upregulated Acetaminophen results in increased expression of SLC25A4 mRNA 4q35.1 Acetaminophen Approved SLC25A40 55972 upregulated Acetaminophen results in increased expression of SLC25A40 mRNA 7q21.12 Acetaminophen Approved SLC25A43 203427 downregulated Acetaminophen results in decreased expression of SLC25A43 mRNA Xq24 Acetaminophen Approved SLC25A44 9673 upregulated Acetaminophen results in increased expression of SLC25A44 mRNA 1q22 Acetaminophen Approved SLC25A45 283130 upregulated Acetaminophen results in increased expression of SLC25A45 mRNA 11q13.1 Acetaminophen Approved SLC25A47 283600 downregulated Acetaminophen results in decreased expression of SLC25A47 mRNA 14q32.2 Acetaminophen Approved SLC25A5 292 upregulated Acetaminophen results in increased expression of SLC25A5 mRNA Xq24 Acetaminophen Approved SLC25A51 92014 upregulated Acetaminophen results in increased expression of SLC25A51 mRNA 9p13.2-p13.1 Acetaminophen Approved SLC25A6 293 downregulated Acetaminophen results in decreased expression of SLC25A6 mRNA Xp22.32 and Yp11.3 Acetaminophen Approved SLC35B3 51000 upregulated Acetaminophen results in increased expression of SLC35B3 mRNA 6p24.3 Acetaminophen Approved SLC9A6 10479 upregulated Acetaminophen results in increased expression of SLC9A6 mRNA Xq26.3 Acetaminophen Approved SLC9B2 133308 downregulated Acetaminophen results in decreased expression of SLC9B2 mRNA 4q24 Acetaminophen Approved SMDT1 91689 downregulated Acetaminophen results in decreased expression of SMDT1 mRNA 22q13.2 Acetaminophen Approved SOD1 6647 upregulated Acetaminophen results in increased expression of SOD1 mRNA 21q22.11 Acetaminophen Approved SPG7 6687 upregulated Acetaminophen results in increased expression of SPG7 mRNA 16q24.3 Acetaminophen Approved SRGAP2 23380 upregulated Acetaminophen results in increased expression of SRGAP2 mRNA 1q32.1 Acetaminophen Approved SSBP1 6742 downregulated Acetaminophen results in decreased expression of SSBP1 mRNA 7q34 Acetaminophen Approved STARD13 90627 downregulated Acetaminophen results in decreased expression of STARD13 mRNA 13q13.1 Acetaminophen Approved STOML2 30968 downregulated Acetaminophen results in decreased expression of STOML2 mRNA 9p13.3 Acetaminophen Approved STXBP1 6812 upregulated Acetaminophen results in increased expression of STXBP1 mRNA 9q34.11 Acetaminophen Approved SUCLG2 8801 downregulated Acetaminophen results in decreased expression of SUCLG2 mRNA 3p14.1 Acetaminophen Approved SUOX 6821 upregulated Acetaminophen results in increased expression of SUOX mRNA 12q13.2 Acetaminophen Approved SUPV3L1 6832 downregulated Acetaminophen results in decreased expression of SUPV3L1 mRNA 10q22.1 Acetaminophen Approved SURF1 6834 upregulated Acetaminophen results in increased expression of SURF1 mRNA 9q34.2 Acetaminophen Approved SYNJ2 8871 downregulated Acetaminophen results in decreased expression of SYNJ2 mRNA 6q25.3 Acetaminophen Approved TAMM41 132001 downregulated Acetaminophen results in decreased expression of TAMM41 mRNA 3p25.2 Acetaminophen Approved TAOK3 51347 upregulated Acetaminophen results in increased expression of TAOK3 mRNA 12q Acetaminophen Approved TARS2 80222 downregulated Acetaminophen results in decreased expression of TARS2 mRNA 1q21.2 Acetaminophen Approved TAT 6898 downregulated Acetaminophen results in decreased expression of TAT mRNA 16q22.2 Acetaminophen Approved TAZ 6901 upregulated Acetaminophen results in increased expression of TAZ mRNA Xq28 Acetaminophen Approved TCAIM 285343 downregulated Acetaminophen results in decreased expression of TCAIM mRNA 3p21.31 Acetaminophen Approved TFAM 7019 downregulated Acetaminophen results in decreased expression of TFAM mRNA 10q21.1 Acetaminophen Approved TFB1M 51106 downregulated Acetaminophen results in decreased expression of TFB1M mRNA 6q25.3 Acetaminophen Approved TFB2M 64216 downregulated Acetaminophen results in decreased expression of TFB2M mRNA 1q44 Acetaminophen Approved TFRC 7037 upregulated Acetaminophen results in increased expression of TFRC mRNA 3q29 Acetaminophen Approved TGM2 7052 upregulated Acetaminophen results in increased expression of TGM2 mRNA 20q11.23 Acetaminophen Approved TIMM10 26519 downregulated Acetaminophen results in decreased expression of TIMM10 mRNA 11q12.1 Acetaminophen Approved TIMM10B 26515 downregulated Acetaminophen results in decreased expression of TIMM10B mRNA 11p15.4 Acetaminophen Approved TIMM44 10469 downregulated Acetaminophen results in decreased expression of TIMM44 mRNA 19p13.2 Acetaminophen Approved TIMM9 26520 downregulated Acetaminophen results in decreased expression of TIMM9 mRNA 14q23.1 Acetaminophen Approved TIMMDC1 51300 upregulated Acetaminophen results in increased expression of TIMMDC1 mRNA 3q13.33 Acetaminophen Approved TMEM143 55260 upregulated Acetaminophen results in increased expression of TMEM143 mRNA 19q13.32 Acetaminophen Approved TMEM256 254863 upregulated Acetaminophen results in increased expression of TMEM256 mRNA 17p13.1 Acetaminophen Approved TMEM8B 51754 upregulated Acetaminophen results in increased expression of TMEM8B mRNA 9p13.3 Acetaminophen Approved TMX4 56255 upregulated Acetaminophen results in increased expression of TMX4 mRNA 20p12.3 Acetaminophen Approved TOMM20 9804 downregulated Acetaminophen results in decreased expression of TOMM20 mRNA 1q42.3 Acetaminophen Approved TOMM22 56993 downregulated Acetaminophen results in decreased expression of TOMM22 mRNA 22q13.1 Acetaminophen Approved TOMM34 10953 upregulated Acetaminophen results in increased expression of TOMM34 mRNA 20q13.12 Acetaminophen Approved TOMM40L 84134 downregulated Acetaminophen results in decreased expression of TOMM40L mRNA 1q23.3 Acetaminophen Approved TOMM5 401505 downregulated Acetaminophen results in decreased expression of TOMM5 mRNA 9p13.2 Acetaminophen Approved TOMM70 9868 downregulated Acetaminophen results in decreased expression of TOMM70 mRNA 3q12.2 Acetaminophen Approved TP53 7157 downregulated Acetaminophen results in decreased expression of TP53 mRNA 17p13.1 Acetaminophen Approved TPP1 1200 upregulated Acetaminophen results in increased expression of TPP1 mRNA 11p15.4 Acetaminophen Approved TRAP1 10131 downregulated Acetaminophen results in decreased expression of TRAP1 mRNA 16p13.3 Acetaminophen Approved TRIT1 54802 downregulated Acetaminophen results in decreased expression of TRIT1 mRNA 1p34.2 Acetaminophen Approved TRMT10C 54931 downregulated Acetaminophen results in decreased expression of TRMT10C mRNA 3q12.3 Acetaminophen Approved TRMU 55687 downregulated Acetaminophen results in decreased expression of TRMU mRNA 22q13.31 Acetaminophen Approved TRNT1 51095 downregulated Acetaminophen results in decreased expression of TRNT1 mRNA 3p26.2 Acetaminophen Approved TSFM 10102 downregulated Acetaminophen results in decreased expression of TSFM mRNA 12q14.1 Acetaminophen Approved TST 7263 upregulated Acetaminophen results in increased expression of TST mRNA 22q12.3 Acetaminophen Approved TWNK 56652 downregulated Acetaminophen results in decreased expression of TWNK mRNA 10q24.31 Acetaminophen Approved TXN2 25828 upregulated Acetaminophen results in increased expression of TXN2 mRNA 22q12.3 Acetaminophen Approved TXNDC12 51060 upregulated Acetaminophen results in increased expression of TXNDC12 mRNA 1p32.3 Acetaminophen Approved UCP2 7351 upregulated Acetaminophen results in increased expression of UCP2 mRNA 11q13 Acetaminophen Approved UQCR10 29796 downregulated Acetaminophen results in decreased expression of UQCR10 mRNA 22q12.2 Acetaminophen Approved UROS 7390 upregulated Acetaminophen results in increased expression of UROS mRNA 10q26.2 Acetaminophen Approved USP30 84749 downregulated Acetaminophen results in decreased expression of USP30 mRNA 12q24.11 Acetaminophen Approved VAMP1 6843 upregulated Acetaminophen results in increased expression of VAMP1 mRNA 12p13.31 Acetaminophen Approved VARS 7407 downregulated Acetaminophen results in decreased expression of VARS mRNA 6p21.33 Acetaminophen Approved VARS2 57176 downregulated Acetaminophen results in decreased expression of VARS2 mRNA 6p21.33 Acetaminophen Approved VDAC3 7419 upregulated Acetaminophen results in increased expression of VDAC3 mRNA 8p11.21 Acetaminophen Approved WARS2 10352 downregulated Acetaminophen results in decreased expression of WARS2 mRNA 1p12 Acetaminophen Approved XAF1 54739 downregulated Acetaminophen results in decreased expression of XAF1 mRNA 17p13.2 Acetaminophen Approved XPNPEP3 63929 upregulated Acetaminophen results in increased expression of XPNPEP3 mRNA 22q13.2 Acetaminophen Approved YARS2 51067 downregulated Acetaminophen results in decreased expression of YARS2 mRNA 12p11.21 Acetaminophen Approved YME1L1 10730 downregulated Acetaminophen results in decreased expression of YME1L1 mRNA 10p12.1 Acetaminophen Approved YRDC 79693 downregulated Acetaminophen results in decreased expression of YRDC mRNA 1p34.3 Acetaminophen Approved ZFHX3 463 downregulated Acetaminophen results in decreased expression of ZFHX3 mRNA 16q22.2-q22.3