Maternal-fetal transfer of saquinavir studied in the ex vivo placental perfusion model.

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Forestier F, de Renty P, Peytavin G, Dohin E, Farinotti R, Mandelbrot L

Maternal-fetal transfer of saquinavir studied in the ex vivo placental perfusion model.

Am J Obstet Gynecol. 2001 Jul;185(1):178-81.

PubMed ID
11483925 [ View in PubMed
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Abstract

OBJECTIVE: This study was undertaken to determine the placental transfer of the human immunodeficiency virus protease inhibitor saquinavir. STUDY DESIGN: An ex vivo perfused human placental cotyledon model was used. Ten placental perfusion studies were performed, with concentrations of saquinavir in the maternal compartment ranging from 322 to 2197 ng/mL (within reference therapeutic ranges). Drug concentrations were determined by high-performance liquid chromatography. RESULTS: The mean (+/- SD) fetal transfer rate of saquinavir was 1.8% +/- 1.6%, and the mean (+/- SD) clearance index was 0.05 +/- 0.05. A mean (+/- SD) of 1.6% +/- 3.1% of the perfused saquinavir was retained by the cotyledon. The small amount of saquinavir that crossed the placenta corresponded to the fraction not bound to human serum albumin. CONCLUSION: The low rate of placental transfer of saquinavir suggests that use of this antiretroviral drug by pregnant women may not lead to significant exposure of the fetus.

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