Oral plasma kallikrein inhibitor BCX7353 for treatment of hereditary angioedema.

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Hwang JR, Hwang G, Johri A, Craig T

Oral plasma kallikrein inhibitor BCX7353 for treatment of hereditary angioedema.

Immunotherapy. 2019 Dec;11(17):1439-1444. doi: 10.2217/imt-2019-0128. Epub 2019 Oct 22.

PubMed ID

31635497 [ View in PubMed

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Abstract

Hereditary angioedema (HAE) is rare disorder caused by a SERPING1 gene mutation that triggers severe swelling of the skin and upper airway. Treatment options for HAE with deficient and dysfunctional C1-inhibitor are expanding to include small-molecule drugs that inhibit protein interactions in the kallikrein-kinin system. Discovered by BioCryst Pharmaceuticals, BCX7353 is a synthetic, once-daily, small molecule drug that can be taken as an oral capsule to treat HAE attacks and for prophylaxis. This article will summarize recent and current BCX7353 clinical trials. Overall, results indicate BCX7353 is a promising form of therapy with a rapid 1 h onset of action, long duration of action, and acceptable tolerance.

DrugBank Data that Cites this Article

Drugs

Berotralstat

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Berotralstat	Plasma kallikrein	Protein	Humans	Yes	Inhibitor	Details