Imlifidase: First Approval.

Article Details

Citation

Al-Salama ZT

Imlifidase: First Approval.

Drugs. 2020 Nov;80(17):1859-1864. doi: 10.1007/s40265-020-01418-5.

PubMed ID
33058042 [ View in PubMed
]
Abstract

Imlifidase (Idefirix(TM)), a cysteine protease derived from the immunoglobulin G (IgG)degrading enzyme of Streptococcus (S.) pyogenes is being developed by Hansa Biopharma AB for treatment of transplant rejection and rare IgG-mediated autoimmune conditions. In August 2020, intravenous imlifidase received its first global approval in the EU for desensitization treatment of highly sensitized adult kidney transplant patients with positive crossmatch against an available deceased donor. Imlifidase is currently undergoing clinical evaluation for the prevention of kidney transplant rejection in the USA, Australia, France and Austria, and clinical development is underway for anti-glomerular basement membrane disease, and for Guillain-Barre syndrome in France, the UK and the Netherlands. This article summarizes the milestones in the development of imlifidase leading to this first approval for desensitization treatment of highly sensitized adult kidney transplant patients with positive crossmatch against an available deceased donor.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
ImlifidaseIgG heavy chain (Protein Group)Protein group
Yes
Cleavage
Details