Evaluating vibegron for the treatment of overactive bladder.
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Rechberger T, Wrobel A
Evaluating vibegron for the treatment of overactive bladder.
Expert Opin Pharmacother. 2020 Sep 29:1-9. doi: 10.1080/14656566.2020.1809652.
- PubMed ID
- 32993398 [ View in PubMed]
- Abstract
INTRODUCTION: Vibegron is a very selective new beta3-adrenergic receptor agonist introduced recently to clinical practice for OAB patients, which offers an alternative option for to antimuscarinic drugs. AREAS COVERED: This review presents the current knowledge concerning the mechanism of action, pharmacokinetics, and pharmacodynamics of vibegron. Moreover, it presents an overview of preclinical and phase II and phase III clinical studies on the efficacy, tolerability, and safety of this agent in patients suffering from OAB. EXPERT OPINION: Clinical studies confirmed efficacy and safety of vibegron in OAB patients. Vibegron differ from well-known mirabegron with regards to its pharmacological pro fi le because it is metabolized independently from CYP3A4, 2D6, or 2C9 and therefore is less likely to cause a drug-drug interaction. Moreover, since this drug does not penetrate the blood-brain barrier, it could become the drug of choice in OAB patients with cognitive impairment. These properties have paved the way in near future for better-tailored treatments for OAB patients.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Vibegron Beta-3 adrenergic receptor Protein Humans YesAgonistDetails - Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareVibegronTrospium Trospium may increase the smooth muscle relaxing activities of Vibegron. VibegronDarifenacin Darifenacin may increase the smooth muscle relaxing activities of Vibegron. VibegronTolterodine Tolterodine may increase the smooth muscle relaxing activities of Vibegron. VibegronOxybutynin Oxybutynin may increase the smooth muscle relaxing activities of Vibegron. VibegronFlavoxate Flavoxate may increase the smooth muscle relaxing activities of Vibegron.