Everything You Always Wanted to Know about beta3-AR * (* But Were Afraid to Ask).

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Schena G, Caplan MJ

Everything You Always Wanted to Know about beta3-AR * (* But Were Afraid to Ask).

Cells. 2019 Apr 16;8(4). pii: cells8040357. doi: 10.3390/cells8040357.

PubMed ID
30995798 [ View in PubMed
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Abstract

The beta-3 adrenergic receptor (beta3-AR) is by far the least studied isotype of the beta-adrenergic sub-family. Despite its study being long hampered by the lack of suitable animal and cellular models and inter-species differences, a substantial body of literature on the subject has built up in the last three decades and the physiology of beta3-AR is unraveling quickly. As will become evident in this work, beta3-AR is emerging as an appealing target for novel pharmacological approaches in several clinical areas involving metabolic, cardiovascular, urinary, and ocular disease. In this review, we will discuss the most recent advances regarding beta3-AR signaling and function and summarize how these findings translate, or may do so, into current clinical practice highlighting beta3-AR's great potential as a novel therapeutic target in a wide range of human conditions.

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