Interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors.
Article Details
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Schoeffter P, Hoyer D
Interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors.
Eur J Pharmacol. 1991 Apr 17;196(2):213-6. doi: 10.1016/0014-2999(91)90432-p.
- PubMed ID
- 1678720 [ View in PubMed]
- Abstract
Oxymetazoline was recognized with nanomolar affinity by 5-HT1A, 5-HT1B and 5-HT1D binding sites and mimicked the effects of 5-hydroxytryptamine with about the same potency and intrinsic activity as the endogenous amine in the corresponding functional tests. At 5-HT1C receptors, oxymetazoline behaved as a mixed agonist-antagonist. Clonidine had minimal activity. Methiothepin antagonized the effects of oxymetazoline (7.4 less than pKB less than 8.8). Thus, oxymetazoline is a full and potent agonist at 5-HT1A, 5-HT1B and 5-HT1D receptors and a partial agonist at 5-HT1C receptors.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Oxymetazoline 5-hydroxytryptamine receptor 1A Protein Humans UnknownAgonistDetails Oxymetazoline 5-hydroxytryptamine receptor 1B Protein Humans UnknownAgonistDetails Oxymetazoline 5-hydroxytryptamine receptor 1C Protein Rat UnknownPartial agonistDetails Oxymetazoline 5-hydroxytryptamine receptor 1D Protein Humans UnknownAgonistDetails