Cimetidine

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Pino MA, Azer SA

Cimetidine

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PubMed ID

31334975 [ View in PubMed

]

Abstract

Cimetidine is a gastric acid reducer used in the short-term treatment of duodenal and gastric ulcers.[1] The drug is effective in managing gastric hypersecretion, and therefore, used for the management of reflux esophagitis disease and in the prevention of stress ulcers. With the development of proton pump inhibitors, such as omeprazole, approved for the same indications, cimetidine is available as an over the counter formulation for the prevention of heartburn or acid indigestion, along with the other H2-receptor antagonists.

DrugBank Data that Cites this Article

Drugs

Cimetidine

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Cimetidine	Histamine H2 receptor	Protein	Humans	Yes	Antagonist	Details

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Cimetidine	Cytochrome P450 1A2	Protein	Humans	Unknown	Inhibitor	Details
Cimetidine	Cytochrome P450 2C9	Protein	Humans	Unknown	Inhibitor	Details
Cimetidine	Cytochrome P450 2D6	Protein	Humans	Unknown	Inhibitor	Details

Food Interactions

Drug	Interaction
Cimetidine	Take with food. Food increases bioavailability. For prophylaxis of gastric symptoms, take cimetidine 30-60 minutes prior to food administration.