Interaction of cimetidine with human serum albumin.

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Wilson CJ, Bogoyevitch MA, Winzor DJ

Interaction of cimetidine with human serum albumin.

Biochem Pharmacol. 1990 Oct 1;40(7):1672-3. doi: 10.1016/0006-2952(90)90472-w.

PubMed ID

2222522 [ View in PubMed

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Abstract

Ultrafiltration studies have detected the existence of a weak interaction between cimetidine and human serum albumin, a finding supported by corresponding studies with this xenobiotic and bovine serum albumin. Furthermore, the binding characteristics of the interaction with human serum albumin (4 sites, K = 630 M-1) more than suffice to account for the proportion of protein-bound drug in the serum of patients subjected to cimetidine therapy. Thus, although alpha 1-acid glycoprotein is usually regarded as the specific transporter of basic drugs, the present evidence implicates albumin as the likely binding protein for cimetidine in serum.

DrugBank Data that Cites this Article

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Cimetidine	Serum albumin	Protein	Humans	Unknown	Substrate	Details