Pharmacological and biological effects of tin-protoporphyrin on neonatal hyperbilirubinemic Gunn rats.

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Nagae H, Keino H, Watanabe K, Kashiwamata S

Pharmacological and biological effects of tin-protoporphyrin on neonatal hyperbilirubinemic Gunn rats.

Pediatr Res. 1988 Aug;24(2):209-12. doi: 10.1203/00006450-198808000-00014.

PubMed ID
3186333 [ View in PubMed
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Abstract

Our study was undertaken to examine the pharmacological and biological effects of tin-protoporphyrin, a competitive inhibitor of heme oxygenase, on 5- or 6-day-old homozygous (j/j) Gunn rats with hereditary unconjugated hyperbilirubinemia. When j/j neonates were injected subcutaneously with 20 mumol of tin-protoporphyrin/kg of body weight, hepatic heme oxygenase activity decreased to 30% of the initial level 2 h after administration and remained low during the next 46 h. However, the reduction of serum bilirubin was more rapid and transient, reaching the minimum value (40% of the initial level) at 1 h and increasing thereafter at a rate almost comparable to that in nontreated j/j rats. The mortality rate of j/j rats was strikingly reduced by the administration of 1 to 100 mumol of tin-protoporphyrin/kg; the most effective dose was 5 mumol/kg (8% compared with 80% in non-treated j/j rats). However, the protective effect of tin-protoporphyrin on bilirubin cerebellopathy (cerebellar hypoplasia) was less marked than expected. Possible implications of our results are discussed.

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