Biomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly.

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Saavedra D, Fuertes SA, Suarez GM, Gonzalez A, Lorenzo-Luaces P, Garcia B, Aznar E, Mazorra Z, Crombet T, Speiser DE, Lage A

Biomodulina T partially restores immunosenescent CD4 and CD8 T cell compartments in the elderly.

Exp Gerontol. 2019 Sep;124:110633. doi: 10.1016/j.exger.2019.110633. Epub 2019 Jun 14.

PubMed ID
31207285 [ View in PubMed
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Abstract

The changes that occur in the immune system with aging are commonly termed immunosenescence. Immunosenescence affects almost all components and functions of the immune response. The most commonly described change is a decrease in numbers and proportions of naive T cells combined with the increase of terminally differentiated T lymphocytes, mainly affecting CD8+ T cells. The changes in the naive T cell compartment are principally attributed to thymic involution and lifelong chronic antigen stimulation, among other triggers. Several strategies such as hormonal products, thymic peptides, or cytokines have been proposed for the restoration of the immune system. Here we show the effects of Biomodulina T (BT) on several populations of the immune system when administered to elderly patients diagnosed with recurrent respiratory infections. BT is a polypeptide fraction of bovine thymus, a Cuban product that obtained sanitary registration in 1994 for its immunomodulatory effects. We found that CD4+ naive T, CD8+ stem cell-like memory (SCM) T, CD4+ recent thymic emigrants (RTE) T and CD4+ CD31+ naive T cells increased with the administration of BT, whereas CD4+ and CD8+ T cells expressing PD1 decreased after the treatment with BT. Additionally, the proliferative capacity of CD4+ T cells measured by Ki67 expression, and the CD4+ T cell ability to produce IFN-gamma were also improved by BT. Moreover, BT did not increase CD4+ Tregs. Altogether, these findings suggest that BT administration is a promising strategy for immune restoration in elderly patients and improvement of immunotherapeutic potential in cancer patients.

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