Muscarinic Receptor Agonists and Antagonists

Article Details

Citation
Copy to clipboard

Broadley KJ, Kelly DR

Muscarinic Receptor Agonists and Antagonists

Molecules. 2001 Feb 28;6(3):142-193.

PubMed ID
Not Available
Abstract

A comprehensive review of pharmacological and medical aspects of the muscarinic class of acetylcholine agonists and antagonists is presented. The therapeutic benefits of achieving receptor subtype selectivity are outlined and applications in the treatment of Alzheimer’s disease are discussed. A selection of chemical routes are described, which illustrate contemporary methodology for the synthesis of chiral medicinal compounds (asymmetric synthesis, chiral pool, enzymes). Routes to bicyclic intrannular amines and intramolecular Diels-Alder reactions are highlighted.

DrugBank Data that Cites this Article

Drugs