Nitrofurantoin and fosfomycin for resistant urinary tract infections: old drugs for emerging problems.

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Citation

Gardiner BJ, Stewardson AJ, Abbott IJ, Peleg AY

Nitrofurantoin and fosfomycin for resistant urinary tract infections: old drugs for emerging problems.

Aust Prescr. 2019 Feb;42(1):14-19. doi: 10.18773/austprescr.2019.002. Epub 2019 Feb 1.

PubMed ID
30765904 [ View in PubMed
]
Abstract

Uncomplicated urinary tract infection is one of the most common indications for antibiotic use in the community However the Gram-negative organisms that can cause the infection are becoming more resistant to antibiotics: Many multidrug resistant organisms retain susceptibility to two old antibiotics nitrofurantoin and fosfomycin Advantages over newer drugs include their high urinary concentrations and minimal toxicity: Fosfomycin is a potential treatment option for patients with uncomplicated urinary tract infection due to resistant organisms Nitrofurantoin may be more effective and can be used for urinary infections in pregnant women:

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