Pindolol potentiates the effect of fluoxetine on hippocampal seizures in rats.

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Wada Y, Hirao N, Shiraishi J, Nakamura M, Koshino Y

Pindolol potentiates the effect of fluoxetine on hippocampal seizures in rats.

Neurosci Lett. 1999 May 21;267(1):61-4. doi: 10.1016/s0304-3940(99)00321-3.

PubMed ID

10400249 [ View in PubMed

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Abstract

Recent studies have shown that behavioral and neurochemical changes induced by selective serotonin (5-HT) reuptake inhibitors such as fluoxetine are potentiated by coadministration of a 5-HT1A receptor antagonist. The present study assessed the effects of concomitant administration of fluoxetine and a 5-HT1A receptor antagonist, pindolol, on focal hippocampal (HIP) seizures elicited by electrical stimulation in rats. A 10 mg/kg dose of fluoxetine, which was ineffective by itself, produced a significant increase in the afterdischarge threshold of HIP seizures when combined with pindolol at 10 mg/kg. The inhibitory effect of this combination was eliminated by pretreatment with parachlorophenylalanine, a depletor of brain 5-HT. These findings suggest that treatments designed to increase 5-HT neurotransmission inhibit the generation of HIP seizures. A combination of fluoxetine with a 5-HT1A receptor antagonist could thus be therapeutically useful for the treatment of depressive symptoms in patients with epilepsy.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Pindolol	5-hydroxytryptamine receptor 1A	Protein	Humans	Unknown	Antagonist Inhibitor Ligand	Details