Daptomycin disrupts membrane potential in growing Staphylococcus aureus.

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Alborn WE Jr, Allen NE, Preston DA

Daptomycin disrupts membrane potential in growing Staphylococcus aureus.

Antimicrob Agents Chemother. 1991 Nov;35(11):2282-7. doi: 10.1128/aac.35.11.2282.

PubMed ID

1666494 [ View in PubMed

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Abstract

Daptomycin (LY146032) caused a calcium-dependent dissipation of the membrane potential (delta psi) in Staphylococcus aureus without noticeably affecting the chemical gradient (delta pH) across the membrane. The effect of daptomycin on membrane energization may account for many of the inhibitory effects on macromolecular biosyntheses and membrane function reported for this antibiotic. Our evidence indicates that the bactericidal activity of daptomycin is dependent on an available delta psi.

DrugBank Data that Cites this Article

Drugs

Daptomycin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Daptomycin	Cytoplasmic membrane	Group	Bacteria	Yes	Incorporation into and destabilization	Details