Inhibition of membrane potential-dependent amino acid transport by daptomycin.

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Allen NE, Alborn WE Jr, Hobbs JN Jr

Inhibition of membrane potential-dependent amino acid transport by daptomycin.

Antimicrob Agents Chemother. 1991 Dec;35(12):2639-42. doi: 10.1128/aac.35.12.2639.

PubMed ID

1687346 [ View in PubMed

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Abstract

Daptomycin inhibits the formation of UDP-N-acetylmuramyl-pentapeptide in Bacillus megaterium by inhibiting active transport of amino acids incorporated into the pentapeptide. The ability of daptomycin to inhibit active transport and peptidoglycan formation may be due to its ability to disrupt the transmembrane electrochemical gradient.

DrugBank Data that Cites this Article

Drugs

Daptomycin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Daptomycin	Cytoplasmic membrane	Group	Bacteria	Yes	Incorporation into and destabilization	Details