GLUT2 is a high affinity glucosamine transporter.

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Uldry M, Ibberson M, Hosokawa M, Thorens B

GLUT2 is a high affinity glucosamine transporter.

FEBS Lett. 2002 Jul 31;524(1-3):199-203. doi: 10.1016/s0014-5793(02)03058-2.

PubMed ID

12135767 [ View in PubMed

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Abstract

When expressed in Xenopus oocytes, GLUT1, 2 and 4 transport glucosamine with V(max) values that are three- to four-fold lower than for glucose. The K(m)s for glucosamine and glucose of GLUT1 and GLUT4 were similar. In contrast, GLUT2 had a much higher apparent affinity for glucosamine than for glucose (K(m)=0.8+/-0.1 mM vs. approximately 17-20 mM). Glucosamine transport by GLUT2 was confirmed in mammalian cells and, using hepatocytes from control or GLUT2-null mice, HgCl(2)-inhibitable glucosamine uptake by liver was shown to be exclusively through GLUT2. These data have implications for glucosamine effects on impaired glucose metabolism and for structure-function studies of transporter sugar binding sites.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Glucosamine	Solute carrier family 2, facilitated glucose transporter member 2	Protein	Humans	Unknown	Substrate	Details