Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation.

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Serio AW, Keepers T, Andrews L, Krause KM

Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation.

EcoSal Plus. 2018 Nov;8(1). doi: 10.1128/ecosalplus.ESP-0002-2018.

PubMed ID

30447062 [ View in PubMed

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Abstract

Aminoglycosides are cidal inhibitors of bacterial protein synthesis that have been utilized for the treatment of serious bacterial infections for almost 80 years. There have been approximately 15 members of this class approved worldwide for the treatment of a variety of infections, many serious and life threatening. While aminoglycoside use declined due to the introduction of other antibiotic classes such as cephalosporins, fluoroquinolones, and carbapenems, there has been a resurgence of interest in the class as multidrug-resistant pathogens have spread globally. Furthermore, aminoglycosides are recommended as part of combination therapy for empiric treatment of certain difficult-to-treat infections. The development of semisynthetic aminoglycosides designed to overcome common aminoglycoside resistance mechanisms, and the shift to once-daily dosing, has spurred renewed interest in the class. Plazomicin is the first new aminoglycoside to be approved by the FDA in nearly 40 years, marking the successful start of a new campaign to rejuvenate the class.

DrugBank Data that Cites this Article

Drugs

Tobramycin

Gentamicin

Streptomycin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Gentamicin	Bacterial outer membrane	Group	Bacteria	Yes	Incorporation into and destabilization	Details
Gentamicin	Cytoplasmic membrane	Group	Bacteria	Yes	Incorporation into and destabilization	Details
Streptomycin	Bacterial outer membrane	Group	Bacteria	Yes	Incorporation into and destabilization	Details
Streptomycin	Cytoplasmic membrane	Group	Bacteria	Yes	Incorporation into and destabilization	Details
Tobramycin	16S ribosomal RNA	Nucleotide	Enteric bacteria and other eubacteria	Yes	Inhibitor	Details
Tobramycin	Bacterial outer membrane	Group	Bacteria	Yes	Incorporation into and destabilization	Details
Tobramycin	Cytoplasmic membrane	Group	Bacteria	Yes	Incorporation into and destabilization	Details