Alveolar epithelial beta2-adrenergic receptors.

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Citation

Mutlu GM, Factor P

Alveolar epithelial beta2-adrenergic receptors.

Am J Respir Cell Mol Biol. 2008 Feb;38(2):127-34. doi: 10.1165/rcmb.2007-0198TR. Epub 2007 Aug 20.

PubMed ID
17709598 [ View in PubMed
]
Abstract

beta(2)-adrenergic receptors are present throughout the lung, including the alveolar airspace, where they play an important role for regulation of the active Na(+) transport needed for clearance of excess fluid out of alveolar airspace. beta(2)-adrenergic receptor signaling is required for up-regulation of alveolar epithelial active ion transport in the setting of excess alveolar edema. The positive, protective effects of beta(2)-adrenergic receptor signaling on alveolar active Na(+) transport in normal and injured lungs provide substantial support for the use of beta-adrenergic agonists to accelerate alveolar fluid clearance in patients with cardiogenic and noncardiogenic pulmonary edema. In this review, we summarize the role of beta(2)-adrenergic receptors in the alveolar epithelium with emphasis on their role in the regulation of alveolar active Na(+) transport in normal and injured lungs.

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