Protein binding and pharmacokinetics of lincomycin following intravenous administration of high doses.

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Gwilt PR, Smith RB

Protein binding and pharmacokinetics of lincomycin following intravenous administration of high doses.

J Clin Pharmacol. 1986 Feb;26(2):87-90. doi: 10.1002/j.1552-4604.1986.tb02911.x.

PubMed ID

3950061 [ View in PubMed

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Abstract

High-dose infusions of lincomycin 600, 1,200, and 2,400 mg were administered to 14 healthy, adult men. Using model-independent pharmacokinetics, it was found that the half-life, mean residence time, and steady-state volume of distribution of total drug increased with dose, whereas the same parameters remained unchanged for the unbound lincomycin. Although the mean clearance value for total drug increased, this change fell short of being significant at the 5% level and was associated with a decrease in unbound clearance following administration of the 2,400 mg dose. Protein binding studies using ultrafiltration gave direct evidence of saturable serum protein binding and indicated that binding involved at least two distinct classes of binding sites.

DrugBank Data that Cites this Article

Drugs

Lincomycin

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Lincomycin	Alpha-1-acid glycoprotein 1	Protein	Humans	No	Binder	Details