Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory.

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Fornari RV, Moreira KM, Oliveira MG

Effects of the selective M1 muscarinic receptor antagonist dicyclomine on emotional memory.

Learn Mem. 2000 Sep-Oct;7(5):287-92. doi: 10.1101/lm.34900.

PubMed ID

11040260 [ View in PubMed

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Abstract

The nonselective muscarinic antagonist scopolamine is known to impair the acquisition of some learning tasks such as inhibitory avoidance. There has been recent research into the effects of this drug in contextual fear conditioning and tone fear conditioning paradigms. The purpose of the present study was to assess the role of the selective M1 muscarinic antagonist dicyclomine in these paradigms and in the inhibitory avoidance test. Rats were administered different doses of dicyclomine or saline 30 min before acquisition training. The animals were tested 24 hr later, and it was observed that 16 mg/kg of dicyclomine impaired both contextual fear conditioning and inhibitory avoidance. However, dicyclomine (up to 64 mg/kg) did not affect tone fear conditioning. These results suggest that the selective M1 muscarinic antagonist dicyclomine differentially affects aversively motivated tasks known to be dependent on hippocampal integrity (such as contextual fear conditioning and inhibitory avoidance) but does not affect similar hippocampus-independent tasks.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Dicyclomine	Muscarinic acetylcholine receptor M1	Protein	Humans	Yes	Antagonist	Details