Prejunctional muscarinic receptors regulating neurotransmitter release in airways.

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Kilbinger H, von Bardeleben RS, Siefken H, Wolf D

Prejunctional muscarinic receptors regulating neurotransmitter release in airways.

Life Sci. 1995;56(11-12):981-7. doi: 10.1016/0024-3205(95)00037-7.

PubMed ID

10188802 [ View in PubMed

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Abstract

Prejunctional pA2 values of five muscarinic antagonists were determined in the guinea-pig trachea under stimulation conditions in which the antagonists alone did not enhance acetylcholine release. The antagonists were partly selective at M1 (pirenzepine), M2 (AQ-RA 741, himbacine) and M3 receptors (hexahydrosiladifenidol, dicyclomine). The profile of the antagonist affinities was different from that obtained at cardiac M2 receptors but resembled the profile reported in the literature for the cloned m4 receptor. This suggests that autoinhibition of acetylcholine release in the trachea is mediated via M4 receptors.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Dicyclomine	Muscarinic acetylcholine receptor M3	Protein	Humans	Unknown	Antagonist	Details