Human African Trypanosomiasis: Progress and Stagnation.

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Citation

Bottieau E, Clerinx J

Human African Trypanosomiasis: Progress and Stagnation.

Infect Dis Clin North Am. 2019 Mar;33(1):61-77. doi: 10.1016/j.idc.2018.10.003.

PubMed ID
30712768 [ View in PubMed
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Abstract

Control efforts have considerably reduced the prevalence of human African trypanosomiasis (HAT) due to Trypanosoma brucei gambiense in West/Central Africa and to Trypanosoma brucei rhodesiense in East Africa. Management of T brucei gambiense HAT has recently improved, with new antibody-based rapid diagnostic tests suited for mass screening and clinical care, and simpler treatments, including the nifurtimox-eflornithine combination therapy and the new oral drug fexinidazole to treat the second stage of the disease. In contrast, no major advance has been achieved for the treatment of T brucei rhodesiense HAT, a zoonosis that occasionally affects short-term travelers to endemic areas.

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