Renal effects of angiotensin II in normotensive subjects on short-term cilazapril treatment.

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Hannedouche T, Ikeni A, Marques LP, Natov S, Dechaux M, Schmitt F, Lacour B, Grunfeld JP

Renal effects of angiotensin II in normotensive subjects on short-term cilazapril treatment.

J Cardiovasc Pharmacol. 1992;19 Suppl 6:S25-7.

PubMed ID

1382161 [ View in PubMed

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Abstract

In 13 normotensive subjects on a normal sodium diet, we studied renal vascular, blood pressure, and hormonal changes induced by infusion of exogenous angiotensin II (Ang II) (5 ng/kg/min) during baseline conditions and after 5 days of cilazapril administration. In both conditions, Ang II elicited a slight pressor response accompanied by renal hemodynamic and hormonal changes that were similar. This suggests that hourly changes in Ang II concentrations and/or in Ang II receptor density after short-term administration of the angiotensin-converting enzyme (ACE) inhibitor cilazapril does not significantly affect renal vascular reactivity. In addition, these results also indirectly suggest that most of the renal effects of ACE inhibition are mediated through suppression of Ang II formation.

DrugBank Data that Cites this Article

Drugs

Spirapril

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Cilazapril	Angiotensin-converting enzyme	Protein	Humans	Yes	Inhibitor	Details
Cilazaprilat	Angiotensin-converting enzyme	Protein	Humans	Yes	Not Available	Details