Effects of colchicine and phenothiazine on biliary excretion of organic anions in rats.

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Takikawa H, Sano N, Akimoto K, Ogasawara T, Yamanaka M

Effects of colchicine and phenothiazine on biliary excretion of organic anions in rats.

J Gastroenterol Hepatol. 1998 Apr;13(4):427-32. doi: 10.1111/j.1440-1746.1998.tb00658.x.

PubMed ID

9641309 [ View in PubMed

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Abstract

Vesicular transport inhibitors have been reported to inhibit biliary excretion of some organic anions, suggesting that vesicular transport has a role in intracellular transport of these compounds. However, these inhibitors are substrates for P-glycoprotein. To examine whether P-glycoprotein has a role in canalicular transport of organic anions in addition to the canalicular multispecific organic anion transporter, we studied the effect of colchicine, a vesicular transport inhibitor, and phenothiazine to increase P-glycoprotein expression on biliary excretion of various organic anions in rats. Colchicine treatment slightly but significantly inhibited biliary excretion of indocyanine green, dinitrophenyl-glutathione and pravastatin, and had no effect on biliary excretion of sulphobromophthalein and dibromosulphophthalein. Phenothiazine treatment did not affect biliary excretion of indocyanine green and pravastatin, but it increased biliary sulphobromophthalein-glutathione excretion. In conclusion, the present findings suggest that P-glycoprotein plays an additive role on biliary excretion of some organic anions in addition to the canalicular multispecific organic anion transporter.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Indocyanine green acid form	Canalicular multispecific organic anion transporter 1	Protein	Humans	No	Substrate	Details