A study of the duration of acute tolerance induced with hexobarbital in male rats.

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Wahlstrom G

A study of the duration of acute tolerance induced with hexobarbital in male rats.

Pharmacol Biochem Behav. 1998 Apr;59(4):945-8.

PubMed ID
9586853 [ View in PubMed
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Abstract

Male rats were infused i.v. with hexobarbital to obtain a burst suppression of 1 s or more in the EEG (SS). At SS the rats were killed and the concentration of hexobarbital was determined by HPLC in three parts of the brain. Acute tolerance (induced by a 1-h exposure at the SS level) was recorded as an approximately 20% increase in brain concentrations of hexobarbital at the last SS during the exposure when compared with concentrations recorded at the first SS in the controls. Increased brain concentrations (approximately 8%) at SS were recorded 24 h after induction of acute tolerance. After 48 h the increase was uncertain. Thus, acute tolerance to hexobarbital could have cumulative properties if new exposures are imposed after 24 h.

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