Neurosteroids: endogenous regulators of the GABA(A) receptor.

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Belelli D, Lambert JJ

Neurosteroids: endogenous regulators of the GABA(A) receptor.

Nat Rev Neurosci. 2005 Jul;6(7):565-75. doi: 10.1038/nrn1703.

PubMed ID

15959466 [ View in PubMed

]

Abstract

GABA(A) (gamma-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are targeted by many clinically important drugs. Certain naturally occurring pregnane steroids can potently and specifically enhance GABA(A) receptor function in a nongenomic (direct) manner, and consequently have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic and anaesthetic properties. These steroids not only act as remote endocrine messengers, but also can be synthesized in the brain, where they modify neuronal activity locally by modulating GABA(A) receptor function. Such 'neurosteroids' can influence mood and behaviour in various physiological and pathophysiological situations, and might contribute to the behavioural effects of psychoactive drugs.

DrugBank Data that Cites this Article

Drugs

Ganaxolone

Drug Interactions

Drugs	Interaction
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Ganaxolone Dronabinol	The risk or severity of sedation, somnolence, and CNS depression can be increased when Dronabinol is combined with Ganaxolone.
Ganaxolone Droperidol	The risk or severity of sedation, somnolence, and CNS depression can be increased when Droperidol is combined with Ganaxolone.
Ganaxolone Methotrimeprazine	The risk or severity of sedation, somnolence, and CNS depression can be increased when Methotrimeprazine is combined with Ganaxolone.
Ganaxolone Mirtazapine	The risk or severity of sedation, somnolence, and CNS depression can be increased when Mirtazapine is combined with Ganaxolone.
Ganaxolone Nabilone	The risk or severity of sedation, somnolence, and CNS depression can be increased when Nabilone is combined with Ganaxolone.