A test of the transmethylation hypothesis in acute schizophrenic patients.

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Carpenter WT Jr, Fink EB, Narasimhachari N, Himwich HE

A test of the transmethylation hypothesis in acute schizophrenic patients.

Am J Psychiatry. 1975 Oct;132(10):1067-71.

PubMed ID
1058643 [ View in PubMed
]
Abstract

Keeping biochemical determinations and clinical judgements independent, the authors investigated three aspects of the transmethylation hypothesis. They found that 26 acutely schizophrenic patients were no more likely to have bufotenine or N,N-dimethyltryptamine present in urine or elevated serum indolethylamine N-methyltransferase activity than 10 normal control subjects. The authors conclude that these are naturally occurring substances which are equally likely to be present in normal and schizophrenic subjects.

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