The influence of dimetindene maleate on the endogenous hydrocortisone synthesis suppressing potency of betamethasone.

Article Details

Citation
Copy to clipboard

Rehn D, Haack D, Vecsei P, Hennings G

The influence of dimetindene maleate on the endogenous hydrocortisone synthesis suppressing potency of betamethasone.

Arzneimittelforschung. 1985;35(6):970-2.

PubMed ID
2862878 [ View in PubMed
]
Abstract

Plasma hydrocortisone (cortisol) levels in 7 healthy volunteers were measured following administration of 0.25 mg betamethasone or 0.25 mg betamethasone and 1 mg dimetindene maleate. The H1-receptor antagonist dimetindene maleate did not influence the hydrocortisone suppressing activity of betamethasone, which was proved by comparison with the published plasma hydrocortisone levels of 162 young healthy untreated volunteers.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
DimetindeneHistamine H1 receptorProteinHumans
Yes
Antagonist
Details