Acetylcholine mediation of the contractile response to histamine in human bladder detrusor muscle.
Article Details
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Rubinstein R, Nissenkorn I, Cohen S
Acetylcholine mediation of the contractile response to histamine in human bladder detrusor muscle.
Eur J Pharmacol. 1987 Oct 6;142(1):45-50. doi: 10.1016/0014-2999(87)90652-2.
- PubMed ID
- 3691636 [ View in PubMed]
- Abstract
In Krebs solution, histamine evokes in human bladder detrusor muscle strips a dose-dependent contractile response which consists of two pharmacologically distinct responses: a high-sensitivity response evoked at 0.4-2 microM histamine, which is potentiated by neostigmine (0.1 microM) or blocked by atropine (0.1 microM) or ranitidine (1 microM); a low-sensitivity response evoked at 4-40 microM histamine and blocked by dimethindene or diphenhydramine. These findings suggest that the contractile response to low doses of histamine is mediated by acetylcholine released from a site proximal to the muscle. This effect of histamine seems to be mediated by a site which is insensitive to the H1 antagonists dimethindene and diphenhydramine but blocked by the H2 antagonist ranitidine.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Dimetindene Histamine H1 receptor Protein Humans YesAntagonistDetails Diphenhydramine Histamine H1 receptor Protein Humans YesAntagonistDetails Ranitidine Histamine H2 receptor Protein Humans YesAntagonistDetails