[Competition of antibacterial drugs for binding sites of human serum albumin].
Article Details
- CitationCopy to clipboard
Aver'eva EV, Kivman GIa, Markovich MN, Shraiber NF, Pognoevskii OT
[Competition of antibacterial drugs for binding sites of human serum albumin].
Antibiot Khimioter. 1988 Jun;33(6):444-8.
- PubMed ID
- 3421769 [ View in PubMed]
- Abstract
Simultaneous binding of two drugs to human serum albumin (HSA) was studied by flow microcalorimetry. The following drug pairs were used: sulfadimethoxine and cefazolin. Sulfadimethoxine and dicloxacillin, sulfadimethoxine and chlortetracycline. A procedure for estimating the calorimetric titration curves in competing binding of the drugs to the HSA homogeneous active site is described. Comparison of the theoretical and experimental titration curves enabled detection of the ligand competition for the biopolymer binding site. It was shown that sulfadimethoxine displaced cefazolin in the HSA active site, the nature of the HSA association with dicloxacillin and sulfadimethoxine was independent and binding of doxycycline or chlortetracycline to HSA had no influence on sulfadimethoxine interaction with protein.
DrugBank Data that Cites this Article
- Drug Carriers
Drug Carrier Kind Organism Pharmacological Action Actions Dicloxacillin Serum albumin Protein Humans UnknownBinderRegulatorDetails Doxycycline Serum albumin Protein Humans UnknownSubstrateBinderDetails Sulfadimethoxine Serum albumin Protein Humans UnknownSubstrateDetails