Safety and pharmacokinetics of ioversol in healthy volunteers.

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Wilkins RA, Whittington JR, Brigden GS, Lahiri A, Heber ME, Hughes LO

Safety and pharmacokinetics of ioversol in healthy volunteers.

Invest Radiol. 1989 Oct;24(10):781-8. doi: 10.1097/00004424-198910000-00011.

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2793391 [ View in PubMed
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Abstract

Ioversol 320, a new nonionic iodinated contrast medium, was injected intravenously into 24 healthy male volunteers using saline as a control. Physical examination, vital signs, electrocardiogram, biochemical and hematological data were recorded before and at intervals after injection. No significant changes were observed. Seventeen volunteers reported no side effects; six volunteers had mild transitory symptoms considered to be related to the contrast medium. The authors conclude that broader clinical trials can be safely conducted to determine safety and tolerability of ioversol.

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