Comparison of pentamidine isethionate and trimethoprim-sulfamethoxazole in the treatment of Pneumocystis carinii pneumonia.

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Hughes WT, Feldman S, Chaudhary SC, Ossi MJ, Cox F, Sanyal SK

Comparison of pentamidine isethionate and trimethoprim-sulfamethoxazole in the treatment of Pneumocystis carinii pneumonia.

J Pediatr. 1978 Feb;92(2):285-91.

PubMed ID

304478 [ View in PubMed

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Abstract

Fifty patients with P. carinii pneumonitis were randomized to receive either pentamidine isethionate or trimethoprim-sulfamethoxazole therapy. Those not responding favorably to the first drug after three or more days of therapy were changed to the alternate drug. Of the 26 patients initially treated with TMP-SMZ, 20 recovered (0.77)-17 after TMP-SMZ alone and three of nine who were crossed over to pentamidine. Of the 24 patients initially treated with pentamidine, 18 recovered (0.75)-14 of 15 who received only pentamidine and four of nine who were crossed over to TMP-SMZ. Abnormal values for blood urea nitrogen, creatinine, or glucose; inflammation at injection sites; or combination of these effects occurred in 14 of the 15 patients treated with pentamidine alone. Only one of the 17 patients treated with TMP-SMZ alone developed any of these abnormalities. This study shows that TMP-SMZ is as effective as pentamidine in the treatment of PCP, and that it offers the advantages of minimal adverse effects, oral administration, and ready availability.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Sulfamethoxazole	Approved	Glucose	increased	Sulfamethoxazole increases the level of Glucose in the blood
Pentamidine	Approved Investigational	Blood urea nitrogen	increased	Pentamidine increases the level of Blood urea nitrogen in the blood
Pentamidine	Approved Investigational	Creatinine	increased	Pentamidine increases the level of Creatinine in the blood
Pentamidine	Approved Investigational	Glucose	increased	Pentamidine increases the level of Glucose in the blood