Pharmacokinetics and safety of cefamandole in infants and children.

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Chang CT, Khan AJ, Agbayani MM, Jhaveri R, Amin I, Evans HE

Pharmacokinetics and safety of cefamandole in infants and children.

Antimicrob Agents Chemother. 1978 Dec;14(6):838-41.

PubMed ID

570372 [ View in PubMed

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Abstract

Cefamandole, a new cephalosporin antibiotic, has greater activity against common pathogens, including Escherichia coli, Haemophilus influenzae, and Proteus (including indole-positive strains), than available cephalosporin drugs. We have evaluated the safety and pharmacokinetics of this drug in 30 infants and children. Blood levels and urinary excretion of the drug were similar to those previously found in adults. The only side effects were mild and transient elevation of serum glutamic oxalacetic transaminase in 12 patients and of blood urea nitrogen in 1 patient in whom serum creatinine remained normal and unchanged.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Cefamandole	Approved Experimental	Blood urea nitrogen	increased	Cefamandole increases the level of Blood urea nitrogen in the blood