Ivosidenib: First Global Approval.
Article Details
- CitationCopy to clipboard
Dhillon S
Ivosidenib: First Global Approval.
Drugs. 2018 Sep;78(14):1509-1516. doi: 10.1007/s40265-018-0978-3.
- PubMed ID
- 30209701 [ View in PubMed]
- Abstract
Ivosidenib (Tibsovo((R))) is a small molecule, orally available inhibitor of mutated cytosolic isocitrate dehydrogenase 1 (IDH1) that is being developed by Agios Pharmaceuticals for the treatment of cancer in patients with IDH1 mutations. The mutated form of the IDH1 enzyme produces a metabolite, 2-hydroxyglutarate (2-HG), which is thought to play a role in the formation and progression of acute myeloid leukaemia (AML), gliomas and other cancers. Elevated 2-HG levels interfere with cellular metabolism and epigenetic regulation, thereby contributing to oncogenesis. Ivosidenib targets the IDH1 metabolic pathway to prevent a build-up of the oncometabolite 2-HG. This article summarizes the milestones in the development of ivosidenib leading to this first approval in the USA for the treatment of patients with relapsed or refractory AML with a susceptible IDH1 mutation. Clinical development for AML, cholangiocarcinoma, glioma, myelodysplastic syndromes and solid tumours is ongoing worldwide.
DrugBank Data that Cites this Article
- Drugs