Bromocriptine increases plasma estradiol-17 beta concentration in amenorrhea patients with normal serum prolactin.

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Seppala M, Unnerus HA, Hirvonen E, Ranta T

Bromocriptine increases plasma estradiol-17 beta concentration in amenorrhea patients with normal serum prolactin.

J Clin Endocrinol Metab. 1976 Aug;43(2):474-7.

PubMed ID

950375 [ View in PubMed

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Abstract

In a series of 23 patients bromocriptine increased the plasma estradiol-17 beta level from 44.0 +/- 9.5 (mean +/- SE) to 144.1 +/- 31.8 pg/ml after 3 - 5 weeks' treatment (p less than 0.01). In normoprolactinemic patients (N = 12) the level increased from 59.6 +/- 16.3 to 186.5 +/- 50.5 pg/ml (p less than 0.05), and in hyperprolactinemic patients (N = 11) the corresponding values were 27.0 +/- 6.2 and 97.8 +/- 34.6 pg/ml (p less than 0.05). Bromocriptine treatment did not significantly alter the FSH and LH levels. The results suggest that bromocriptine treatment induces endocrine recovery also in patients whose clinical findings give no indication of prolactin suppression.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Bromocriptine	Approved Investigational Withdrawn	Estradiol	increased	Bromocriptine increases the level of Estradiol in the blood