A comparison of the effects of chlorothiazide and of metolazone in the treatment of hypertension.

Article Details

Citation

Hua AS, Kincaid-Smith P

A comparison of the effects of chlorothiazide and of metolazone in the treatment of hypertension.

Clin Sci Mol Med Suppl. 1976 Dec;3:627s-629s.

PubMed ID
1071694 [ View in PubMed
]
Abstract

1. A cross-over study was done in twenty patients with hypertension to compare the effects of chlorothiazide (0-5 g twice daily) and metolazone (5 mg daily) in combination with other anti-hypertensive agents. 2. Compared with absence of diuretic therapy, chlorothiazide and metolazone both produced significantly lower blood pressures. 3. Blood pressures on metolazone tended to be lower than on chlorothiazide but this difference was not statistically significant. 4. Both diuretics significantly lowered serum potassium concentrations and total body potassium to a similar degree, but the serum potassium did not fall below the normal range in any patient and no potassium supplements were needed. No electrocardiographic changes suggestive of hypokalaemia were noted. 5. Small but significant increases in serum bicarbonate, calcium, urea and acid were observed with both diuretics. 6. Patient acceptance was excellent and no adverse effects were encountered.

DrugBank Data that Cites this Article

Pharmaco-metabolomics
DrugDrug GroupsMetaboliteChangeDescription
ChlorothiazideApproved Vet ApprovedUrea
increased
Chlorothiazide increases the level of Urea in the blood