Effect of estramustine phosphate on plasma testosterone during treatment of carcinoma of prostate.

Article Details

Citation

Kjaer TB, Nilsson T, Madsen PO

Effect of estramustine phosphate on plasma testosterone during treatment of carcinoma of prostate.

Urology. 1975 Jun;5(6):802-4.

PubMed ID
1136096 [ View in PubMed
]
Abstract

Estramustine phosphate administered orally at 900 mg. daily depressed plasma testosterone levels in 10 consecutive patients who had previously been treated with estrogen hormones and/or orchiectomy and who were all in relapse from carcinoma of the prostate. Approximately one half of the patients responded to the treatment clinically. The decrease in plasma testosterone did not correlate with the clinical response. The clinical effect of estramustine phosphate may be due to decreased plasma testosterone levels, inhibiton of 5-alpha reductase activity, and a local cytotoxic effect.

DrugBank Data that Cites this Article

Pharmaco-metabolomics
DrugDrug GroupsMetaboliteChangeDescription
EstramustineApproved InvestigationalTestosterone
decreased
Estramustine decreases the level of Testosterone in the blood