Lithium in combination with perphenazine: effect on plasma monoamine metabolites.

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Bowers MB Jr, Mazure CM, Nelson JC, Jatlow PI

Lithium in combination with perphenazine: effect on plasma monoamine metabolites.

Biol Psychiatry. 1992 Dec 15;32(12):1102-7.

PubMed ID

1477190 [ View in PubMed

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Abstract

The addition of lithium to perphenazine altered the pattern of plasma homovanillic acid (HVA) during the course of treatment for acute psychosis. In the perphenazine-treated group plasma HVA declined significantly by days 7-9 of treatment, whereas in the perphenazine-plus-lithium group plasma HVA tended to increase. The pattern for plasma methoxyhydroxyphenethyl-glycol (MHPG) was not significantly different for the two groups. The addition of lithium to a neuroleptic may enhance the metabolism of dopamine.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Perphenazine	Approved	Homovanillic acid	decreased	Perphenazine decreases the level of Homovanillic acid in the blood
Perphenazine	Approved	Homovanillic acid	increased	Perphenazine increases the level of Homovanillic acid in the blood