Modulation of arachidonate metabolite generation in human blood by oral defibrotide.
Article Details
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Biagi G, Legnani C, Rodorigo G, Coccheri S
Modulation of arachidonate metabolite generation in human blood by oral defibrotide.
Arzneimittelforschung. 1991 May;41(5):511-4.
- PubMed ID
- 1654908 [ View in PubMed]
- Abstract
Acute intravenous administration in man of defibrotide (CAS 83712-60-1), a polynucleotide derivative, induces increase of 6-keto-PGF1 alpha and PGE2 production from appropriately stimulated whole blood. In the present study including acute and chronic experiments, defibrotide (Prociclide) orally administered during two weeks to healthy volunteers significantly increased the amounts of 6-keto-PGF1 alpha generated after appropriate stimulation in whole blood and in a neutrophilic leukocytes-platelet suspension. Similar effects were observed for PGE2, while TXB2 production was unchanged. Furthermore, platelet aggregation induced by calcium ionophore A23817 and production of leukotriene B4 from whole blood and isolated polymorphonuclear neutrophils were inhibited. The observed results suggest that defibrotide is biochemically active also by the oral route although the pharmacological and clinical value of the observed changes needs to be assessed.
DrugBank Data that Cites this Article
- Pharmaco-metabolomics
Drug Drug Groups Metabolite Change Description Defibrotide Approved Investigational Leukotriene B4 decreased Defibrotide decreases the level of Leukotriene B4 in the blood Defibrotide Approved Investigational 6-keto-PGF1 alpha increased Defibrotide increases the level of 6-keto-PGF1 alpha in the blood Defibrotide Approved Investigational Prostaglandin E2 increased Defibrotide increases the level of Prostaglandin E2 in the blood