Modulation of arachidonate metabolite generation in human blood by oral defibrotide.

Article Details

Citation

Biagi G, Legnani C, Rodorigo G, Coccheri S

Modulation of arachidonate metabolite generation in human blood by oral defibrotide.

Arzneimittelforschung. 1991 May;41(5):511-4.

PubMed ID
1654908 [ View in PubMed
]
Abstract

Acute intravenous administration in man of defibrotide (CAS 83712-60-1), a polynucleotide derivative, induces increase of 6-keto-PGF1 alpha and PGE2 production from appropriately stimulated whole blood. In the present study including acute and chronic experiments, defibrotide (Prociclide) orally administered during two weeks to healthy volunteers significantly increased the amounts of 6-keto-PGF1 alpha generated after appropriate stimulation in whole blood and in a neutrophilic leukocytes-platelet suspension. Similar effects were observed for PGE2, while TXB2 production was unchanged. Furthermore, platelet aggregation induced by calcium ionophore A23817 and production of leukotriene B4 from whole blood and isolated polymorphonuclear neutrophils were inhibited. The observed results suggest that defibrotide is biochemically active also by the oral route although the pharmacological and clinical value of the observed changes needs to be assessed.

DrugBank Data that Cites this Article

Pharmaco-metabolomics
DrugDrug GroupsMetaboliteChangeDescription
DefibrotideApproved InvestigationalLeukotriene B4
decreased
Defibrotide decreases the level of Leukotriene B4 in the blood
DefibrotideApproved Investigational6-keto-PGF1 alpha
increased
Defibrotide increases the level of 6-keto-PGF1 alpha in the blood
DefibrotideApproved InvestigationalProstaglandin E2
increased
Defibrotide increases the level of Prostaglandin E2 in the blood