Longitudinal effect of amitriptyline and fluoxetine treatment on plasma phenylacetic acid concentrations in depression.

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Davis BA, Boulton AA, Yu PH, Durden DA, Keegan DL, Bowen RC, Blackshaw S, D'Arcy C, Remillard AJ, Dayal N, et al.

Longitudinal effect of amitriptyline and fluoxetine treatment on plasma phenylacetic acid concentrations in depression.

Biol Psychiatry. 1991 Sep 15;30(6):600-8.

PubMed ID

1932407 [ View in PubMed

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Abstract

Unconjugated (U-PAA), conjugated (C-PAA), and total phenylacetic acid (T-PAA) concentrations in blood plasma and monoamine oxidase (MAO) activity in platelets towards phenylethylamine (PE) were determined in 40 drug-free, depressed patients (23 melancholic, 17 nonmelancholic) from five psychiatric treatment centers, and in 34 normal healthy volunteers. No significant differences were found between controls and all depressed patients or between melancholic and nonmelancholic depressed patients. Treatment of the depressed patients with amitriptyline or fluoxetine over a 6-week period resulted in clinical improvement and in a significant increase in plasma PAA concentrations. A decline in the Beck and Hamilton rating scores during treatment correlated significantly with increases in the concentrations of unconjugated, conjugated, and total phenylacetic acid but not with MAO activity, which did not change during treatment. At each of the three assessment times, however, plasma PAA concentrations and psychiatric rating scores were not significantly correlated. Except for higher end-of-study T-PAA concentrations in the amitriptyline-treated subjects, no significant differences were found between the effects of the two drugs with regard to plasma phenylacetic acid levels, MAO activity, or rating scores.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Amitriptyline	Approved	Phenylacetic acid (unconjugated)	increased	Amitriptyline increases the level of Phenylacetic acid (unconjugated) in the blood
Amitriptyline	Approved	Phenylacetic acid (conjugated)	increased	Amitriptyline increases the level of Phenylacetic acid (conjugated) in the blood
Amitriptyline	Approved	Phenylacetic acid (total)	increased	Amitriptyline increases the level of Phenylacetic acid (total) in the blood
Fluoxetine	Approved Vet Approved	Phenylacetic acid (unconjugated)	increased	Fluoxetine increases the level of Phenylacetic acid (unconjugated) in the blood
Fluoxetine	Approved Vet Approved	Phenylacetic acid (conjugated)	increased	Fluoxetine increases the level of Phenylacetic acid (conjugated) in the blood
Fluoxetine	Approved Vet Approved	Phenylacetic acid (total)	increased	Fluoxetine increases the level of Phenylacetic acid (total) in the blood