Nitrendipine is a potent inhibitor of the Ca(2+)-activated K+ channel of human erythrocytes.

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Ellory JC, Kirk K, Culliford SJ, Nash GB, Stuart J

Nitrendipine is a potent inhibitor of the Ca(2+)-activated K+ channel of human erythrocytes.

FEBS Lett. 1992 Jan 20;296(2):219-21. doi: 10.1016/0014-5793(92)80383-r.

PubMed ID

1733781 [ View in PubMed

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Abstract

Nitrendipine, a classical blocker of L-type Ca2+ channels, is shown to be a potent inhibitor of the Ca(2+)-activated K+ channel of human erythrocytes. In erythrocytes suspended in a solution with physiological Na+ and K+ concentrations and in which the channel was activated using the Ca2+ ionophore ionomycin, nitrendipine inhibited K+(86Rb+) influx with an I50 of around 130 nM. Similar results were obtained for K+(86Rb+) efflux, and for K+(86Rb+) influx into cells suspended in a high-K+ medium.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Nitrendipine	Calcium-activated potassium channel (Protein Group)	Protein group	Humans	Unknown	Inhibitor	Details